Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Benegut perilla is a proprietary extract derived from Perilla frutescens (commonly known as perilla or shiso), a plant traditionally used in East Asian medicine. Recent scientific interest has focused on its potential benefits for respiratory allergies, such as allergic rhinitis and asthma. Several in vitro and animal studies suggest that perilla extracts possess anti-inflammatory and anti-allergic properties, likely mediated through inhibition of histamine release, suppression of pro-inflammatory cytokines (such as IL-4 and IL-13), and modulation of immune cell activity. Some small-scale human studies and preliminary clinical trials indicate that perilla extracts may help reduce symptoms of seasonal allergies, including sneezing, nasal congestion, and itching, though these studies often use standardized extracts rather than specific proprietary blends like Benegut perilla.

However, the clinical evidence remains limited: most studies feature small sample sizes, short durations, and methodological limitations. There is moderate preclinical evidence supporting perilla’s mechanisms of action for allergy relief, but robust, large-scale, placebo-controlled human trials are lacking. As a result, the use of Benegut perilla for respiratory allergies is scientifically plausible and supported by early research, but the overall strength of evidence is modest, meriting a rating of 2 out of 5.

In summary, while there is some scientific basis for using perilla extracts to support respiratory allergy relief, more rigorous clinical research is needed before strong recommendations can be made.

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