Evidence supporting the use of: Bifobacterium (mixed)
For the health condition: Allergies (respiratory)

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Bifidobacterium (mixed strains) have been investigated for their potential role in supporting or treating respiratory allergies, such as allergic rhinitis and asthma. The rationale is based on the "hygiene hypothesis," which suggests that disruptions in the gut microbiota may contribute to the development of allergic diseases. Several clinical studies and systematic reviews have explored the effects of probiotics, including Bifidobacterium species, on allergic outcomes. Some randomized controlled trials (RCTs) have reported modest improvements in symptoms or quality of life among individuals with allergic rhinitis who received mixed Bifidobacterium supplements. However, results are inconsistent, and the magnitude of benefit is generally small. Meta-analyses indicate that while probiotics may reduce the risk of developing allergic diseases in children, the evidence is less robust for the treatment of established respiratory allergies in adults.

The proposed mechanisms involve modulation of immune responses, such as enhancing regulatory T cell function and reducing pro-inflammatory cytokines. There is some mechanistic evidence from animal studies and human trials showing changes in immune markers after Bifidobacterium supplementation. However, due to heterogeneity in probiotic strains, dosages, and study populations, current guidelines do not recommend Bifidobacterium probiotics as a standard treatment for respiratory allergies. In summary, there is some scientific evidence suggesting a potential benefit, but it is not strong or conclusive.

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