Evidence supporting the use of: Bioflavonoid
For the health condition: Allergies (respiratory)

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Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Bioflavonoids, also known as flavonoids, have a long history of traditional use in managing allergies, particularly respiratory allergies such as hay fever. Historically, they have been used in herbal medicine, often in conjunction with vitamin C, to “strengthen capillaries” and reduce allergic symptoms like runny nose, sneezing, and watery eyes. The rationale was based on observations that bioflavonoids could decrease histamine release from mast cells and reduce inflammation, both of which are central to allergic responses. Notably, quercetin—a well-known bioflavonoid—has been a popular supplement for allergy sufferers.

Scientifically, there is some in vitro and animal evidence that certain bioflavonoids can inhibit the release of histamines and other mediators from immune cells associated with allergic reactions. However, robust clinical trials in humans are limited and results are mixed. Some small studies suggest potential benefit, but systematic reviews generally conclude that the evidence is insufficient to recommend bioflavonoids as a primary or adjunctive therapy for respiratory allergies. Thus, while traditional use is well established and there is biological plausibility, definitive scientific validation is lacking at this time.

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