Relationship: Allergies (respiratory) and citrus bioflavonoids

Evidence supporting the use of: Citrus bioflavonoids
For the health condition: Allergies (respiratory)

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Source of validity: Scientific
Rating (out of 5): 2

Citrus bioflavonoids, a group of compounds found in citrus fruits, are sometimes used to support respiratory allergies such as allergic rhinitis. The rationale behind their use is primarily based on their antioxidant and anti-inflammatory properties, as well as their ability to stabilize mast cells and reduce histamine release in laboratory studies. Several preclinical studies and a small number of clinical trials have suggested that bioflavonoids like hesperidin and quercetin (though not exclusive to citrus) may reduce symptoms associated with allergies by modulating immune responses and inhibiting inflammatory mediators. For example, quercetin has been shown in animal models and some human studies to decrease the severity of allergic reactions by preventing the release of histamine from mast cells. However, the evidence specific to citrus-derived bioflavonoids (such as hesperidin and naringenin) is limited and not as robust as for other flavonoids.

Overall, while there is a plausible scientific mechanism and some supportive laboratory and preliminary clinical data, well-designed, large-scale human trials are lacking. Thus, the evidence supporting the use of citrus bioflavonoids for respiratory allergies is modest but not entirely absent, and further research is needed to confirm their efficacy and optimal dosing in this context.

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Evidence supporting the use of: Citrus bioflavonoids
For the health condition: Allergies (respiratory)

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Evidence supporting the use of: Citrus bioflavonoidsFor the health condition: Allergies (respiratory)

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Synopsis

Other ingredients used for Allergies (respiratory)

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Evidence supporting the use of: Citrus bioflavonoids
For the health condition: Allergies (respiratory)