Evidence supporting the use of: Cortisol
For the health condition: Allergies (respiratory)

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Synopsis

Source of validity: Scientific
Rating (out of 5): 5

Cortisol, or more commonly its synthetic analogs known as corticosteroids (such as prednisone or hydrocortisone), is extensively used and scientifically validated for the treatment of respiratory allergies, including allergic rhinitis and asthma. Corticosteroids work by mimicking the effects of cortisol, a natural hormone produced by the adrenal glands, to suppress inflammation and the immune response that underlies allergic reactions.

Numerous randomized controlled trials and systematic reviews have demonstrated the efficacy of inhaled, oral, and intranasal corticosteroids in reducing symptoms and improving lung function in patients with respiratory allergies. Inhaled corticosteroids are considered the first-line treatment for persistent asthma and are also pivotal in the management of moderate to severe allergic rhinitis. They decrease airway hyper-responsiveness, reduce mucus production, and inhibit the recruitment of inflammatory cells such as eosinophils and mast cells.

Clinical guidelines from organizations such as the Global Initiative for Asthma (GINA) and the American Academy of Allergy, Asthma & Immunology (AAAAI) recommend corticosteroids based on robust scientific evidence. However, long-term or systemic use can lead to side effects, so the lowest effective dose is advised. In summary, the use of cortisol (as corticosteroids) for respiratory allergies is strongly supported by scientific evidence and forms the cornerstone of modern allergy management.

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Products containing cortisol

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