Evidence supporting the use of: Lactobacillus gasseri
For the health condition: Allergies (respiratory)

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Lactobacillus gasseri is a probiotic bacterium that has been investigated for its potential role in modulating immune responses, particularly in the context of respiratory allergies such as allergic rhinitis and asthma. The scientific rationale is based on the observation that certain probiotic strains can influence the balance of Th1/Th2 immune responses and enhance regulatory T cell activity, potentially reducing allergic inflammation. Several small-scale clinical studies and animal models have explored the effect of L. gasseri supplementation on respiratory allergic symptoms. For example, a randomized, double-blind, placebo-controlled study published in Clinical and Experimental Allergy (2015) found that L. gasseri supplementation reduced nasal symptoms and improved quality of life in adults with perennial allergic rhinitis. Other studies, however, have produced mixed results, with some showing minimal or no effect. The evidence base is still relatively limited, with most studies being short-term, small, and sometimes using mixed probiotic formulations. Large-scale, well-controlled clinical trials are lacking. As a result, while there is some scientific validation for the use of L. gasseri in supporting respiratory allergy management, the overall strength of the evidence is modest, and it is not yet considered a standard or primary therapy for such conditions.

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