Evidence supporting the use of: Lactobacillus paracasei
For the health condition: Allergies (respiratory)

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Lactobacillus paracasei has been studied for its potential role in supporting and alleviating respiratory allergies, such as allergic rhinitis. The use of this probiotic is justified primarily by emerging scientific evidence, although the overall quality and quantity of this evidence are still limited.

Several randomized controlled trials and animal studies suggest that L. paracasei may modulate immune responses associated with allergies. The proposed mechanism involves influencing the balance between Th1 and Th2 immune responses, reducing IgE production, and enhancing the function of regulatory T-cells, which can help decrease allergic inflammation. For example, some clinical studies have shown that supplementation with L. paracasei can reduce symptoms of allergic rhinitis, such as nasal congestion and sneezing, and improve quality of life during pollen season. A few trials have demonstrated reductions in specific inflammatory markers and improvements in symptom scores compared to placebo.

However, the evidence is not robust or universally consistent. Many studies have small sample sizes, short durations, or use different strains and dosages, making direct comparisons challenging. Meta-analyses and systematic reviews acknowledge the potential benefits but often conclude that larger, well-designed trials are needed to confirm efficacy and establish optimal usage guidelines.

In summary, L. paracasei is supported by early scientific evidence for the support and possible treatment of respiratory allergies, but the strength of this evidence is moderate at best (rated 2/5). It should not replace established allergy treatments, but may be considered as an adjunct under professional guidance.

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