Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Perilla (Perilla frutescens), particularly its leaves and seeds, has been traditionally used in East Asian medicine, but in recent decades, some scientific research has explored its potential for managing respiratory allergies. This interest stems largely from the plant’s rich content of polyphenols, flavonoids, and rosmarinic acid—compounds known for their anti-inflammatory and immunomodulatory properties. Preclinical studies, including animal and in vitro experiments, have demonstrated that perilla extracts can inhibit the release of histamine and suppress inflammatory cytokines involved in allergic responses, such as interleukin-4 (IL-4) and immunoglobulin E (IgE) production. These actions suggest a potential benefit in reducing symptoms of allergic rhinitis and asthma.

A few small clinical studies have been conducted in humans. For example, one placebo-controlled trial found that perilla seed extract reduced nasal symptoms in individuals with seasonal allergies. However, these clinical studies are limited by small sample sizes and short durations. No large-scale, high-quality randomized controlled trials have definitively established the efficacy or safety of perilla for respiratory allergies in humans.

Overall, while there is promising preclinical data and preliminary human evidence, the current scientific support for perilla in treating respiratory allergies is modest and not conclusive. More rigorous, large-scale clinical trials are needed to substantiate its therapeutic potential and clarify appropriate dosing and safety.

More about perilla
More about Allergies (respiratory)

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