Synopsis

Source of validity: Scientific
Rating (out of 5): 1

2-Hydroxypropyl-Beta-Cyclodextrin (HP-β-CD) has recently gained attention as a potential therapeutic agent for neurodegenerative diseases, including Alzheimer’s disease (AD). The scientific interest stems primarily from its capacity to modulate cholesterol and lipid metabolism, processes that are implicated in the pathophysiology of AD. Preclinical studies, particularly in animal models, have demonstrated that HP-β-CD can reduce amyloid-beta accumulation and improve cognitive performance, possibly by enhancing cholesterol clearance and promoting lysosomal function. For instance, studies in transgenic mouse models of AD have shown that HP-β-CD treatment may decrease amyloid plaque burden and ameliorate associated neuroinflammation.

However, the evidence supporting its use in humans is minimal and largely limited to very early-stage or anecdotal clinical investigations. Most clinical research involving HP-β-CD has focused on Niemann-Pick disease type C, a rare lysosomal storage disorder, rather than Alzheimer’s. There are ongoing and planned clinical trials to evaluate its safety and efficacy in AD, but as of now, no robust clinical data confirm its benefit for this condition.

In summary, while there is emerging preclinical evidence and a plausible mechanistic rationale for HP-β-CD’s use in Alzheimer’s disease, the current level of evidence is low and not yet sufficient to justify clinical use outside of research settings.

More about 2-Hydroxypropyl-Beta-Cyclodextrin
More about Alzheimer's Disease

Other ingredients used for Alzheimer's Disease

Acai berry
Acetyl L-carnitine
Akkermansia muciniphila
algal oil
alpha-linolenic acid (ALA)
amino acids
anthocyanins
ashwagandha
astaxanthin
berberine
berry flavor
beta caryophyllene
bifidobacterium longum
black garlic
black tea
blueberry
broccoli
butyrate triglyceride
caffeine
cannabis sativa oil
caprylic acid
catechins
Chinese salvia root
chokeberry
choline
cinnamon
citicoline
coenzyme Q10 (CoQ10)
turmeric
curcumin
cyclodextrin
d-alpha tocopherol
DHA (docosahexaeonic acid)
DPA (docosapentaenoic acid)
EPA (eicosapentaenoic acid)
epigallocatechin gallate (EGCG)
fisetin
fish oil
fish protein
flavonols
gamma tocopherol
genistein
ginkgo biloba
ginseng
glycerophosphocholine (GPC)
grape
green tea
hemp oil
hesperetin
hesperidin
huperzine A
l-carnitine
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lentinula edodes mycelia
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lutein
luteolin
lycopene
mackerel
magnesium
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matcha
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naringin
niacinamide (Vitamin B3)
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olive
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oyster mushroom
phenolic compounds
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phosphatidylserine
phospholipids
phytocannabinoids
polygala root
pomegranate
pregnenolone
butyric acid
pyrroloquinoline disodium salt
quercetin
reishi mushroom
resveratrol
rhizome
rosemary
saffron
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selenium
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vitamin B
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gastrodia
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terpene lactones
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hypothalamus
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Other health conditions supported by 2-Hydroxypropyl-Beta-Cyclodextrin

Alzheimer's Disease

Products containing 2-Hydroxypropyl-Beta-Cyclodextrin

We currently have no products on Vitabase that contain this ingredient.