Evidence supporting the use of: Alpha-Lipoic Acid
For the health condition: Alzheimer's Disease

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Alpha-Lipoic Acid (ALA) is an antioxidant that has been investigated for its potential role in neurodegenerative diseases, including Alzheimer's Disease (AD). The rationale for its use is based on its antioxidant properties and its ability to regenerate other antioxidants, modulate mitochondrial function, and potentially reduce oxidative stress, which is implicated in AD pathogenesis. Several small clinical studies and pilot trials have explored ALA supplementation in AD patients. For example, a 2007 open-label study suggested that ALA might slow cognitive decline in patients with AD, as measured by standard cognitive assessments, when added to standard treatments. However, these studies have been limited by small sample sizes, lack of placebo controls, and short duration.

Meta-analyses and systematic reviews to date conclude that, while preclinical data and early clinical reports are promising, there is insufficient high-quality evidence to recommend ALA as a standard treatment for Alzheimer's Disease. Major guidelines do not endorse its use for AD. Overall, the scientific support for ALA in AD is weak to modest, warranting a rating of 2/5 for evidence. Larger, well-controlled randomized trials are needed to establish efficacy and safety. There is no substantial tradition of use for AD, and its use is driven by modern scientific hypotheses and exploratory studies.

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Products containing Alpha-Lipoic Acid

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