Evidence supporting the use of: Apocynin
For the health condition: Alzheimer's Disease

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Apocynin is a naturally occurring compound derived from the root of Picrorhiza kurroa and has been studied primarily for its ability to inhibit NADPH oxidase, an enzyme complex involved in the production of reactive oxygen species (ROS). Its potential relevance to Alzheimer's Disease (AD) is based on preclinical research indicating that oxidative stress and neuroinflammation play key roles in the progression of AD pathology. Animal studies and in vitro experiments have shown that apocynin can reduce oxidative damage, decrease amyloid-beta accumulation, and improve cognitive performance in rodent models of Alzheimer's. For example, a 2017 study in mice demonstrated that apocynin treatment reduced neuroinflammation and improved memory deficits.

However, while preclinical findings are promising, there is a lack of robust human clinical trials evaluating apocynin's efficacy or safety in people with Alzheimer's Disease. As such, the evidence supporting its use in this context is limited to laboratory and animal models, and its application in humans remains unproven. No historical or traditional use of apocynin for Alzheimer's has been documented; its proposed use is based on modern pharmacological research only. In summary, while there is scientific rationale and some experimental evidence, the clinical relevance remains uncertain, warranting a low-to-moderate evidence rating.

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Products containing Apocynin

We currently have no products on Vitabase that contain this ingredient.