Evidence supporting the use of: Bacopasides
For the health condition: Alzheimer's Disease

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Bacopasides are a group of saponins found in Bacopa monnieri, a plant traditionally used in Ayurvedic medicine for enhancing memory and cognitive function. Modern scientific studies have investigated Bacopa monnieri and its bacopasides for potential neuroprotective effects relevant to Alzheimer's disease (AD). Preclinical research (mostly in vitro and animal studies) suggests that bacopasides may exert antioxidant, anti-inflammatory, and anti-amyloidogenic effects, which could theoretically help slow AD progression. Some mechanisms proposed include inhibition of beta-amyloid aggregation, reduction of oxidative stress in neuronal tissue, and enhancement of cholinergic function.

However, direct evidence for bacopasides themselves in human Alzheimer's patients is very limited. Most clinical trials on Bacopa monnieri have focused on cognitive enhancement in healthy adults or older adults with mild cognitive impairment, not specifically in AD patients. While these studies sometimes show modest improvements in memory and attention, methodological limitations and variability in extract composition make it difficult to draw firm conclusions about efficacy in Alzheimer's disease. To date, there are no large, high-quality randomized controlled trials directly assessing bacopasides in AD patients.

In summary, while there is promising preclinical evidence and some supportive data from related cognitive studies, the use of bacopasides for Alzheimer's disease is not strongly validated by clinical trials. The evidence for its use is thus rated as 2 (weak to moderate preclinical support, minimal clinical validation).

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anthocyanins
ashwagandha
astaxanthin
berberine
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beta caryophyllene
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DPA (docosapentaenoic acid)
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epigallocatechin gallate (EGCG)
fisetin
fish oil
fish protein
flavonols
gamma tocopherol
genistein
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glycerophosphocholine (GPC)
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hemp oil
hesperetin
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l-serine
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lycopene
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phenolic acids
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phosphatidylserine
phospholipids
phytocannabinoids
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Products containing Bacopasides

We currently have no products on Vitabase that contain this ingredient.