Evidence supporting the use of: Baicalin
For the health condition: Alzheimer's Disease

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Baicalin is a flavonoid compound derived from the roots of Scutellaria baicalensis (Chinese skullcap), a traditional herb used in East Asian medicine. In recent years, baicalin has been investigated in preclinical studies for its potential neuroprotective effects, including applications in Alzheimer’s Disease (AD). The scientific basis for its use is primarily supported by laboratory and animal research. Studies indicate that baicalin may exert anti-inflammatory, antioxidant, and anti-apoptotic effects in neuronal cells. In Alzheimer’s models, baicalin has been shown to inhibit beta-amyloid aggregation, reduce neuroinflammation, and improve cognitive performance in rodents. Mechanisms proposed include modulation of the MAPK and NF-κB signaling pathways, inhibition of acetylcholinesterase, and upregulation of neurotrophic factors.

However, there is currently a lack of robust clinical trials in humans demonstrating efficacy or safety of baicalin for treating or preventing Alzheimer’s Disease. Most evidence is limited to in vitro or animal studies, and while these findings are promising, translation to human medicine remains unproven. Baicalin is not widely recognized in Western clinical guidelines for AD, but its use is an area of ongoing research. In summary, the use of baicalin for Alzheimer’s is scientifically motivated by preclinical data, but human evidence is insufficient, warranting a low-to-moderate rating of 2 on the evidence scale.

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Products containing Baicalin

We currently have no products on Vitabase that contain this ingredient.