Evidence supporting the use of: Berberine
For the health condition: Alzheimer's Disease

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Berberine is a plant alkaloid found in several medicinal herbs, including Berberis vulgaris (barberry) and Coptis chinensis (goldthread). In recent years, it has attracted scientific interest for its potential neuroprotective properties, including possible benefits in Alzheimer's disease (AD). Experimental studies (primarily in vitro and in animal models) have suggested that berberine may exert multiple mechanisms relevant to AD pathology: it can inhibit acetylcholinesterase (increasing acetylcholine levels), reduce amyloid-beta aggregation, attenuate oxidative stress, and decrease neuroinflammation. For instance, a 2015 study in rats showed that berberine administration improved cognitive performance and reduced amyloid plaque burden. Other studies have found that berberine can modulate signaling pathways involved in neurodegeneration, such as the PI3K/Akt and AMPK pathways.

However, there is only limited evidence from human studies. Most clinical research on berberine focuses on metabolic disorders (such as diabetes and hyperlipidemia), not Alzheimer's disease. There are currently no large, high-quality randomized controlled trials in humans directly evaluating berberine for AD. Thus, while preclinical data are promising and suggest a scientific rationale, the evidence base is still early and insufficient to recommend berberine as a treatment for Alzheimer's disease. More rigorous clinical research is needed to validate its effectiveness and safety in this context.

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Other ingredients used for Alzheimer's Disease

2-(carbamimidoyl-methyl-amino) ethoxyphosphonic acid
7,14-Hydroxy-Docosapentaenoic Acid
7,8-Dihydroxyflavone
Acacetin
Acai berry
Acetyl L-carnitine
Acetylcholine
Agmatine
Akkermansia muciniphila
Algae
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alpha-linolenic acid (ALA)
alpha-lipoic acid
amentoflavone
amino acids
AMP-activated protein kinase (AMPK)
ampelopsin
aniracetam
anserine
anthocyanins
apigenin
apocynin
Aronia melanocarpa
ashwagandha
astaxanthin
astragaloside
avocado
Bacopa
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bacoside
baicalein
baicalin
Basidiomycota
benfotiamine
berberine
beta caryophyllene
beta-hydroxybutyrate
Bifidobacteria
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bilobalide
black garlic
black seed
black tea
blueberry
brahmi
broccoli
butylphthalide
butyrate triglyceride
butyric acid
C-phycocyanin
caffeic Acid
caffeine
Camellia sinensis
cannabigerol
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caprylic acid
carnosic acid
Carnosine
caryophyllene
catalpol
catechins
centrophenoxine
Chinese Ligustrum berry
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chokeberry
choline
Cinnamomum
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cistanche
citicoline
cocoa
coenzyme Q10 (CoQ10)
Convolvulus prostratus
creatine
crocetin
crocin
Curcuma
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cyanidin
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cytidine
d-alpha tocopherol
decursin
DHA (docosahexaenoic acid)
dihydrolipoic acid
docosahexaenoic Acid
DPA (docosapentaenoic acid)
Ecklonia
eicosapentaenoic acid
ellagic acid
EPA (eicosapentaenoic acid)
epicatechin
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ergothioneine
estrogen
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fisetin
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flavanols
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fo-ti
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gamma tocopherol
ganoderma
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