Evidence supporting the use of: Bifidobacterium longum
For the health condition: Alzheimer's Disease

Links: Go back one page, Tool main page, Ingredients list, Health conditions list, Body systems list

Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Bifidobacterium longum is a probiotic bacterium that has been studied for its potential role in supporting cognitive function, including in Alzheimer’s Disease (AD). The scientific rationale for its use stems from the emerging understanding of the gut-brain axis, which refers to the bidirectional communication network linking the gastrointestinal tract and the central nervous system. Research has identified alterations in gut microbiota composition in patients with Alzheimer's Disease, and probiotics like B. longum are being investigated for their ability to modulate this dysbiosis.

Preclinical studies in animal models of AD have shown that administration of B. longum can reduce neuroinflammation, improve memory, and decrease amyloid-beta plaque deposition, likely through anti-inflammatory effects and the modulation of gut-derived metabolites. For example, a 2019 study in mice found that B. longum supplementation led to improved cognitive performance and reduced markers of neuroinflammation. Some small human studies and clinical trials have evaluated multi-strain probiotics (sometimes including B. longum) in people with mild cognitive impairment or AD, with modest improvements in cognitive scores and inflammation markers.

However, the number of high-quality human clinical trials focusing specifically on B. longum and Alzheimer's Disease is limited, and most evidence is indirect or from animal studies. Thus, while there is scientific interest and a plausible biological mechanism, the evidence is still preliminary and not robust enough for strong clinical recommendations. More large-scale, well-controlled human studies are needed to confirm efficacy.

More about Bifidobacterium longum
More about Alzheimer's Disease

Other ingredients used for Alzheimer's Disease

Acai berry
Acetyl L-carnitine
Akkermansia muciniphila
algal oil
alpha-linolenic acid (ALA)
amino acids
anthocyanins
ashwagandha
astaxanthin
berberine
berry flavor
beta caryophyllene
Bifidobacterium longum
black garlic
black tea
blueberry
broccoli
butyrate triglyceride
caffeine
Cannabis sativa oil
caprylic acid
catechins
Chinese salvia root
chokeberry
choline
cinnamon
citicoline
coenzyme Q10 (CoQ10)
turmeric
curcumin
cyclodextrin
d-alpha tocopherol
DHA (docosahexaenoic acid)
DPA (docosapentaenoic acid)
EPA (eicosapentaenoic acid)
epigallocatechin gallate (EGCG)
fisetin
fish oil
fish protein
flavonols
gamma tocopherol
genistein
ginkgo biloba
ginseng
glycerophosphocholine (GPC)
grape
green tea
hemp oil
hesperetin
hesperidin
huperzine A
l-carnitine
L-carnosine
L-serine
L-theanine
Lentinula edodes mycelia
lion's mane
lutein
luteolin
lycopene
magnesium
Marine lipid
Matcha
medium chain triglycerides (MCT)
Melatonin
N-acetyl-cysteine (NAC)
Naringin
Niacinamide (vitamin B3)
nicotinamide riboside
olive
omega-3 fatty acids
oyster mushroom
phenolic compounds
phosphatidylcholine
phosphatidylserine
phospholipids
phytocannabinoids
polygala root
pomegranate
pregnenolone
butyric acid
pyrroloquinoline disodium salt
quercetin
reishi mushroom
resveratrol
rhizome
rosemary
saffron
sage
SAMe (S-adenosyl-L-methionine disulfate p-toluensulfate)
selenium
sulforaphane glucosinolate
tocotrienols
Trans-pterostilbene
tributyrin
ubiquinol
Urolithin A
Vinpocetine
vitamin B
vitamin B12
vitamin C
vitamin D
vitamin D3
vitamin E
Mulberry
β-nicotinamide mononucleotide (NMN)
gastrodia
Tinospora cordifolia
lingzhi
Morus
ferulic acid
cistanche
ganoderma
royal jelly
terpene lactones
polyphenols
herbal blend (proprietary)
Algae
cocoa
AMP-activated protein kinase (AMPK)
soy isoflavones
2-(carbamimidoyl-methyl-amino) ethoxyphosphonic acid
7,8-Dihydroxyflavone
7,14-Hydroxy-Docosapentaenoic Acid
apigenin
Aronia melanocarpa
anserine
avocado
Agmatine
Acetylcholine
amentoflavone
Acacetin
alpha-lipoic acid
astragaloside
ampelopsin
aniracetam
apocynin
black seed
bilobalide
butylphthalide
beta-hydroxybutyrate
Bacopin
baicalein
benfotiamine
Basidiomycota
brahmi
Bacopa
Bifidobacteria
bacoside
baicalin
caffeic Acid
centrophenoxine
Camellia sinensis
caryophyllene
Cinnamomum
crocin
Carnosine
catalpol
cyanidin
Curcuminoid
curcumen
Chinese Ligustrum berry
creatine
Curcuma
C-phycocyanin
Convolvulus prostratus
crocetin
cytidine
carnosic acid
cannabigerol
docosahexaenoic Acid
decursin
dihydrolipoic acid
epicatechin
ellagic acid
ergothioneine
eicosapentaenoic acid
estrogen
Ecklonia
flavonoids
fo-ti
fish
fatty acids
fungus
flavanones
flavans
flavonones
flavanols
flavones
gallic acid
Ginsenosides
garcinol
ginkgetin
galantamine
Gypenoside
gallate
ginkgolides
ginkgo flavone glycoside
Ginkgoside
ginkgoheteroside
Glucoraphanin
gastrodin
Honokiol
Hyperoside
Hericenones
hydroxytyrosol
hericium mushroom
hemp
Homotaurine
iridoids
isoliquiritigenin
isovitexin
icariin
Kaempferol
ketone salts
Lycium
lipids
Maslinic acid
Methylcobalamin
mangiferin
Mulberroside A
Myricitrin
Monoterpenes
Myricetin
Monounsaturated fat
malvidin
Marine fat
Methoxylated flavones
magnolol
NADH
Norvaline
Naringenin
Nigella seed
Nobiletin
Nervonic acid
Oleuropein
Osthole
Phycocyanin
pyrroloquinoline quinone
Piperine
polysaccharides
Pentacyclic triterpenoids
Polydatin
polyunsaturated fat
punicalagins
paeoniflorin
Pycnogenol
Phytoestrogens
polymethoxylated flavones
Polygala
Peptides
rosmarinic acid
Schizochytrium Oil
Solanaceae
Soy
Schizochytrium
Selenocysteine
Salmon Oil
Salidroside
Syringic acid
Shankhpushpi
Salvianolic acid
Shogaol
Schisandrins
Shilajit
Safranal
S-allylcysteine
Sarcosine
Stilbenoid
Sulforaphane
Terpenoids
Tumerone
Taxifolin
Triterpenes
Tangeretin
Trehalose
Taurine
Theaflavin
Turmerones
Tremella
Uncaria
Ursolic Acid
Uridine
Withanolides
Wogonin
Walnut
Xanthohumol
Xanthophyll
Xylaria nigripes