Evidence supporting the use of: Cistanche (unspecified)
For the health condition: Alzheimer's Disease

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Cistanche, particularly Cistanche tubulosa and Cistanche deserticola, is a traditional Chinese medicinal herb sometimes used in Asia to support memory and cognitive function. Recent years have seen an increase in scientific investigation into its potential for treating or supporting Alzheimer's Disease (AD), though evidence remains preliminary and mostly preclinical.

Research suggests that Cistanche contains bioactive compounds such as echinacoside and acteoside, which possess antioxidant, anti-inflammatory, and neuroprotective properties. Animal studies and in vitro experiments have shown that extracts from Cistanche can reduce amyloid-beta accumulation, mitigate oxidative stress, and improve cognitive deficits in rodent models of AD. For example, a 2016 study in Evidence-Based Complementary and Alternative Medicine found that Cistanche extract improved learning and memory in AD model mice, potentially by modulating synaptic plasticity and neuroinflammation.

Despite these promising findings, there is a lack of robust clinical evidence in humans. Most available data comes from animal studies or cell culture experiments, with only a few small-scale human studies addressing cognitive outcomes, often as part of multi-herb formulations rather than Cistanche alone.

In summary, while there is a scientific rationale and some preclinical evidence supporting the use of Cistanche in Alzheimer's Disease, clinical validation is lacking. Further human studies are required to establish efficacy and safety. Thus, the scientific evidence supporting its use in AD is limited and preliminary (evidence rating: 2/5).

More about Cistanche (unspecified)
More about Alzheimer's Disease

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amino acids
anthocyanins
ashwagandha
astaxanthin
berberine
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beta caryophyllene
bifidobacterium longum
black garlic
black tea
blueberry
broccoli
butyrate triglyceride
caffeine
cannabis sativa oil
caprylic acid
catechins
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chokeberry
choline
cinnamon
citicoline
coenzyme Q10 (CoQ10)
turmeric
curcumin
cyclodextrin
d-alpha tocopherol
DHA (docosahexaeonic acid)
DPA (docosapentaenoic acid)
EPA (eicosapentaenoic acid)
epigallocatechin gallate (EGCG)
fisetin
fish oil
fish protein
flavonols
gamma tocopherol
genistein
ginkgo biloba
ginseng
glycerophosphocholine (GPC)
grape
green tea
hemp oil
hesperetin
hesperidin
huperzine A
l-carnitine
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l-serine
l-theanine
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lutein
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lycopene
mackerel
magnesium
marine lipid
matcha
medium chain triglycerides (MCT)
melatonin
n-acetyl-cysteine (NAC)
naringin
niacinamide (vitamin B3)
nicotinamide riboside
olive
omega-3 fatty acids
oyster mushroom
phenolic acids
phosphatidylcholine
phosphatidylserine
phospholipids
phytocannabinoids
polygala root
pomegranate
pregnenolone
butyric acid
pyrroloquinoline disodium salt
quercetin
reishi mushroom
resveratrol
rhizome
rosemary
saffron
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SAMe (s-adenosyl-l-methionine disulfate p-toluensulfate)
sardines
selenium
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tocotrienols
trans-pterostilbene
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ubiquinol
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vitamin B
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vitamin C
vitamin D
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vitamin E
mulberry
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gastrodia
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lingzhi
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ferulic acid
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ganoderma
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polyphenols
hypothalamus
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Caryophyllene
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Catalpol
Cyanidin
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Creatine
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Crocetin
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Products containing Cistanche (unspecified)

We currently have no products on Vitabase that contain this ingredient.