Evidence supporting the use of: Delivery system
For the health condition: Alzheimer's Disease

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Delivery systems, such as nanoparticles, liposomes, and other drug delivery vehicles, are used to support or treat Alzheimer's Disease (AD) due to significant scientific challenges in delivering therapeutic agents across the blood-brain barrier (BBB). The BBB is a major obstacle in treating neurological diseases because it restricts the passage of most drugs from the bloodstream into the brain. Scientific research has therefore focused on designing delivery systems that can enhance the transport, stability, and bioavailability of drugs targeting Alzheimer's pathology.

Preclinical studies have shown that delivery systems can improve brain uptake of anti-amyloid, antioxidant, or neuroprotective agents. For example, nanoparticle-based formulations of curcumin, donepezil, or rivastigmine have demonstrated improved delivery to the brain and enhanced pharmacological effects in animal models of AD. Liposomes and polymeric nanoparticles have also been used to encapsulate drugs and peptides, protecting them from degradation and enhancing their penetration into the brain.

However, while these delivery approaches are scientifically validated in preclinical settings, there is limited evidence from large-scale human clinical trials demonstrating their efficacy and safety in AD patients. Most current data come from laboratory and animal studies, and translation to clinical use is still ongoing. Thus, while the rationale is scientific and research is promising, the evidence base for clinical effectiveness in humans is still emerging, justifying a moderate evidence rating.

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amino acids
anthocyanins
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astaxanthin
berberine
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beta caryophyllene
bifidobacterium longum
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blueberry
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caprylic acid
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citicoline
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DHA (docosahexaeonic acid)
DPA (docosapentaenoic acid)
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epigallocatechin gallate (EGCG)
fisetin
fish oil
fish protein
flavonols
gamma tocopherol
genistein
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ginseng
glycerophosphocholine (GPC)
grape
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hemp oil
hesperetin
hesperidin
huperzine A
l-carnitine
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l-serine
l-theanine
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lutein
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lycopene
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magnesium
marine lipid
matcha
medium chain triglycerides (MCT)
melatonin
n-acetyl-cysteine (NAC)
naringin
niacinamide (vitamin B3)
nicotinamide riboside
olive
omega-3 fatty acids
oyster mushroom
phenolic acids
phosphatidylcholine
phosphatidylserine
phospholipids
phytocannabinoids
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Products containing Delivery system

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