Synopsis

Source of validity: Scientific
Rating (out of 5): 2

DHA (docosahexaenoic acid) is an omega-3 fatty acid found abundantly in the brain and is essential for normal neuronal function. Its use in supporting or treating Alzheimer’s Disease (AD) is based on scientific rationale and some clinical investigation, but the overall evidence is limited and mixed, justifying a modest evidence rating.

Epidemiological studies have observed that populations with higher dietary intake of omega-3 fatty acids, including DHA, tend to have lower rates of cognitive decline and dementia. Preclinical research in animal models and cell cultures suggests that DHA can reduce amyloid-beta accumulation, decrease neuroinflammation, and support synaptic plasticity—all processes implicated in AD pathogenesis.

However, clinical trials in humans have produced inconsistent results. Some randomized controlled trials show that DHA supplementation may modestly slow cognitive decline in individuals with mild cognitive impairment (MCI) or in early stages of Alzheimer’s, especially among those with low baseline omega-3 status or without the APOE ε4 allele. Other trials, particularly in patients with moderate to severe AD, have failed to demonstrate significant cognitive benefits.

Systematic reviews and meta-analyses generally conclude that while DHA is important for brain health, its supplementation provides limited or no significant benefit in established Alzheimer’s Disease. The evidence is stronger for a potential preventive role rather than a therapeutic one. Thus, while there is some scientific basis for DHA’s use in AD, more research is needed to clarify its effectiveness and identify which patients may benefit most.

More about DHA (docosahexaenoic acid)
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Other health conditions supported by DHA (docosahexaenoic acid)

Products containing DHA (docosahexaenoic acid)

Thorne Advanced DHA
Vitabase Brain Support
Vitabase Complete Essential Fatty Acids
Pure Encapsulations DHA Ultimate
Pure Encapsulations DHA Ultimate
Pure Encapsulations EFA Essentials
Pure Encapsulations Energize Plus™ Pure Pack
Pure Encapsulations EPA/DHA
Pure Encapsulations EPA/DHA essentials 1,000 mg
Pure Encapsulations EPA/DHA essentials 1,000 mg
Vitabase EPA / DHA Omega-3
Pure Encapsulations EPA/DHA with Lemon
Pure Encapsulations EPA Ultimate
Klean Athlete Klean Omega ™
Douglas Laboratories Krill Oil
Pure Encapsulations Krill-Plex
Pure Encapsulations Krill-Plex
Metagenics MetaKids DHA
Metagenics MetaKids Nutrition Powder Chocolate
Metagenics MetaKids Nutrition Powder Vanilla
Pure Encapsulations NeuroMood Pure Pack
Pure Encapsulations O.N.E.™ Omega
Pure Encapsulations O.N.E.™ Omega
Thorne Omega-3 w/ CoQ10
Thorne Omega Superb Lemon Berry
Metagenics OmegaGenics Algae EPA-DHA 300 mg
Metagenics OmegaGenics EPA DHA 2400 Fish Oil
Metagenics OmegaGenics EPA-DHA 300 Lemon Lime
Metagenics OmegaGenics Fish Oil EPA-DHA 1000 mg
Metagenics OmegaGenics Fish Oil EPA-DHA 1000 mg
Metagenics OmegaGenics Fish Oil EPA-DHA 500 mg
Metagenics OmegaGenics Fish Oil EPA-DHA 500 mg
Metagenics OmegaGenics Fish Oil EPA-DHA 720 mg
Metagenics OmegaGenics Fish Oil EPA-DHA 720 mg
Metagenics OmegaGenics Fish Oil EPA-DHA 720 mg
Metagenics OmegaGenics Fish Oil Mega 10®
Metagenics OmegaGenics Neuro 1000 mg
Designs For Health OmegAvail™ Hi-Po
Designs For Health OmegAvail™ Hi-Po
Designs For Health OmegAvail™ Hi-Po Liquid
Designs For Health OmegAvail™ Liquid
Designs For Health OmegAvail™ Synergy
Designs For Health OmegAvail™ Synergy
Designs For Health OmegAvail™ TG1000
Designs For Health OmegAvail™ Ultra
Designs For Health OmegAvail™ Ultra
Designs For Health OmegAvail™ Ultra DHA
Designs For Health OmegAvail™ Ultra with Vitamin D3, K1 and K2
Douglas Laboratories Opti-EPA 500 ™ Cholesterol Free
Douglas Laboratories Opti-EPA 500 ™ Cholesterol Free
Metagenics PlusOne® Daily Prenatal Packs
Thorne Prenatal DHA
Pure Encapsulations Pro-Resolve Omega
Thorne Pro-Resolving Mediators
Integrative Therapeutics Pure Omega HP
Integrative Therapeutics Pure Omega Liquid
Integrative Therapeutics Pure Omega Ultra HP
Pure Encapsulations PureNutrients EPA/DHA
Douglas Laboratories QÜELL® FISH OIL DHA Ultra SPM
Douglas Laboratories QUELL Fish Oil ® - EPA/DHA Plus D
Metagenics SPM Active
Thorne Super EPA
Thorne Super EPA NSF
Thorne Super EPA Pro
Vitabase Super Omega-3
Douglas Laboratories Ultra G.L.A. Borage Oil
Douglas Laboratories Ultra G.L.A. Borage Oil
Pure Encapsulations Ultra Pure Pack
Pure Encapsulations VisionPro EPA/DHA/GLA
Pure Encapsulations VisionPro EPA/DHA/GLA
Metagenics Wellness Essentials Active Daily Packs
Metagenics Wellness Essentials Brain Health Daily Packs
Metagenics Wellness Essentials® Daily Packs
Metagenics Wellness Essentials Healthy Balance Daily Packs
Metagenics Wellness Essentials Men's Vitality Daily Packs
Metagenics Wellness Essentials Women's Daily Packs
Metagenics Wellness Essentials Women's Prime Daily Packs
Designs For Health XanthOmega™ Krill Oil