Evidence supporting the use of: EPA (eicosapentaenoic acid)
For the health condition: Alzheimer's Disease

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Eicosapentaenoic acid (EPA) is an omega-3 polyunsaturated fatty acid found in fish oil, and its potential benefits in Alzheimer's Disease (AD) have been the subject of scientific investigation. EPA is thought to exert neuroprotective effects through anti-inflammatory mechanisms, as chronic neuroinflammation is implicated in AD pathogenesis. Several observational studies suggest that higher dietary intake of omega-3 fatty acids, including EPA, may be associated with a reduced risk of cognitive decline and dementia. However, intervention trials with EPA (alone or as part of fish oil supplementation) in AD patients have yielded mixed results.

A few randomized controlled trials, such as the OmegAD study, assessed the impact of omega-3 supplementation (including EPA) on cognitive decline in AD patients, but results generally showed little or no significant benefit in slowing disease progression. Some post hoc analyses indicate that patients with very mild cognitive impairment or certain genetic backgrounds (e.g., non-APOE4 carriers) might benefit more, but these findings are inconsistent and require further validation. The 2020 Cochrane review concluded that there is insufficient evidence to recommend omega-3 supplementation for people with dementia due to a lack of clinically meaningful effects.

In summary, while there is a plausible biological rationale and some preliminary data suggesting a possible protective effect of EPA, robust clinical evidence supporting its use in the treatment or prevention of Alzheimer's Disease is limited. The current body of evidence rates as weak (2 out of 5), and EPA cannot be considered a proven therapy for Alzheimer's Disease at this time.

More about EPA (eicosapentaenoic acid)
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Other ingredients used for Alzheimer's Disease

Acai berry
Acetyl L-carnitine
Akkermansia muciniphila
algal oil
alpha-linolenic acid (ALA)
amino acids
anthocyanins
ashwagandha
astaxanthin
berberine
berry flavor
beta caryophyllene
Bifidobacterium longum
black garlic
black tea
blueberry
broccoli
butyrate triglyceride
caffeine
Cannabis sativa oil
caprylic acid
catechins
Chinese salvia root
chokeberry
choline
cinnamon
citicoline
coenzyme Q10 (CoQ10)
turmeric
curcumin
cyclodextrin
d-alpha tocopherol
DHA (docosahexaenoic acid)
DPA (docosapentaenoic acid)
EPA (eicosapentaenoic acid)
epigallocatechin gallate (EGCG)
fisetin
fish oil
fish protein
flavonols
gamma tocopherol
genistein
ginkgo biloba
ginseng
glycerophosphocholine (GPC)
grape
green tea
hemp oil
hesperetin
hesperidin
huperzine A
l-carnitine
L-carnosine
L-serine
L-theanine
Lentinula edodes mycelia
lion's mane
lutein
luteolin
lycopene
magnesium
Marine lipid
Matcha
medium chain triglycerides (MCT)
Melatonin
N-acetyl-cysteine (NAC)
Naringin
Niacinamide (vitamin B3)
nicotinamide riboside
olive
omega-3 fatty acids
oyster mushroom
phenolic compounds
phosphatidylcholine
phosphatidylserine
phospholipids
phytocannabinoids
polygala root
pomegranate
pregnenolone
butyric acid
pyrroloquinoline disodium salt
quercetin
reishi mushroom
resveratrol
rhizome
rosemary
saffron
sage
SAMe (S-adenosyl-L-methionine disulfate p-toluensulfate)
selenium
sulforaphane glucosinolate
tocotrienols
Trans-pterostilbene
tributyrin
ubiquinol
Urolithin A
Vinpocetine
vitamin B
vitamin B12
vitamin C
vitamin D
vitamin D3
vitamin E
Mulberry
β-nicotinamide mononucleotide (NMN)
gastrodia
Tinospora cordifolia
lingzhi
Morus
ferulic acid
cistanche
ganoderma
royal jelly
terpene lactones
polyphenols
herbal blend (proprietary)
Algae
cocoa
AMP-activated protein kinase (AMPK)
soy isoflavones
2-(carbamimidoyl-methyl-amino) ethoxyphosphonic acid
7,8-Dihydroxyflavone
7,14-Hydroxy-Docosapentaenoic Acid
apigenin
Aronia melanocarpa
anserine
avocado
Agmatine
Acetylcholine
amentoflavone
Acacetin
alpha-lipoic acid
astragaloside
ampelopsin
aniracetam
apocynin
black seed
bilobalide
butylphthalide
beta-hydroxybutyrate
Bacopin
baicalein
benfotiamine
Basidiomycota
brahmi
Bacopa
Bifidobacteria
bacoside
baicalin
caffeic Acid
centrophenoxine
Camellia sinensis
caryophyllene
Cinnamomum
crocin
Carnosine
catalpol
cyanidin
Curcuminoid
curcumen
Chinese Ligustrum berry
creatine
Curcuma
C-phycocyanin
Convolvulus prostratus
crocetin
cytidine
carnosic acid
cannabigerol
docosahexaenoic Acid
decursin
dihydrolipoic acid
epicatechin
ellagic acid
ergothioneine
eicosapentaenoic acid
estrogen
Ecklonia
flavonoids
fo-ti
fish
fatty acids
fungus
flavanones
flavans
flavonones
flavanols
flavones
gallic acid
Ginsenosides
garcinol
ginkgetin
galantamine
Gypenoside
gallate
ginkgolides
ginkgo flavone glycoside
Ginkgoside
ginkgoheteroside
Glucoraphanin
gastrodin
Honokiol
Hyperoside
Hericenones
hydroxytyrosol
hericium mushroom
hemp
Homotaurine
iridoids
isoliquiritigenin
isovitexin
icariin
Kaempferol
ketone salts
Lycium
lipids
Maslinic acid
Methylcobalamin
mangiferin
Mulberroside A
Myricitrin
Monoterpenes
Myricetin
Monounsaturated fat
malvidin
Marine fat
Methoxylated flavones
magnolol
NADH
Norvaline
Naringenin
Nigella seed
Nobiletin
Nervonic acid
Oleuropein
Osthole
Phycocyanin
pyrroloquinoline quinone
Piperine
polysaccharides
Pentacyclic triterpenoids
Polydatin
polyunsaturated fat
punicalagins
paeoniflorin
Pycnogenol
Phytoestrogens
polymethoxylated flavones
Polygala
Peptides
rosmarinic acid
Schizochytrium Oil
Solanaceae
Soy
Schizochytrium
Selenocysteine
Salmon Oil
Salidroside
Syringic acid
Shankhpushpi
Salvianolic acid
Shogaol
Schisandrins
Shilajit
Safranal
S-allylcysteine
Sarcosine
Stilbenoid
Sulforaphane
Terpenoids
Tumerone
Taxifolin
Triterpenes
Tangeretin
Trehalose
Taurine
Theaflavin
Turmerones
Tremella
Uncaria
Ursolic Acid
Uridine
Withanolides
Wogonin
Walnut
Xanthohumol
Xanthophyll
Xylaria nigripes

Products containing EPA (eicosapentaenoic acid)

Thorne Advanced DHA
Vitabase Complete Essential Fatty Acids
Pure Encapsulations DHA Ultimate
Pure Encapsulations DHA Ultimate
Pure Encapsulations EFA Essentials
Pure Encapsulations Energize Plus™ Pure Pack
Pure Encapsulations EPA/DHA
Pure Encapsulations EPA/DHA essentials 1,000 mg
Pure Encapsulations EPA/DHA essentials 1,000 mg
Vitabase EPA / DHA Omega-3
Pure Encapsulations EPA/DHA with Lemon
Pure Encapsulations EPA Ultimate
Klean Athlete Klean Omega ™
Douglas Laboratories Krill Oil
Pure Encapsulations Krill-Plex
Pure Encapsulations Krill-Plex
Metagenics MetaKids DHA
Pure Encapsulations NeuroMood Pure Pack
Pure Encapsulations O.N.E.™ Omega
Pure Encapsulations O.N.E.™ Omega
Thorne Omega-3 w/ CoQ10
Thorne Omega Superb Lemon Berry
Metagenics OmegaGenics Algae EPA-DHA 300 mg
Metagenics OmegaGenics EPA DHA 2400 Fish Oil
Metagenics OmegaGenics EPA-DHA 300 Lemon Lime
Metagenics OmegaGenics Fish Oil
Metagenics OmegaGenics Fish Oil EPA 1200 mg
Metagenics OmegaGenics Fish Oil EPA-DHA 1000 mg
Metagenics OmegaGenics Fish Oil EPA-DHA 1000 mg
Metagenics OmegaGenics Fish Oil EPA-DHA 500 mg
Metagenics OmegaGenics Fish Oil EPA-DHA 500 mg
Metagenics OmegaGenics Fish Oil EPA-DHA 720 mg
Metagenics OmegaGenics Fish Oil EPA-DHA 720 mg
Metagenics OmegaGenics Fish Oil EPA-DHA 720 mg
Metagenics OmegaGenics Fish Oil Mega 10®
Metagenics OmegaGenics Neuro 1000 mg
Designs For Health OmegAvail™ Hi-Po
Designs For Health OmegAvail™ Hi-Po
Designs For Health OmegAvail™ Hi-Po Liquid
Designs For Health OmegAvail™ Liquid
Designs For Health OmegAvail™ Synergy
Designs For Health OmegAvail™ Synergy
Designs For Health OmegAvail™ TG1000
Designs For Health OmegAvail™ Ultra
Designs For Health OmegAvail™ Ultra
Designs For Health OmegAvail™ Ultra DHA
Designs For Health OmegAvail™ Ultra with Vitamin D3, K1 and K2
Douglas Laboratories Opti-EPA 500 ™ Cholesterol Free
Douglas Laboratories Opti-EPA 500 ™ Cholesterol Free
Metagenics PlusOne® Daily Prenatal Packs
Thorne Prenatal DHA
Pure Encapsulations Pro-Resolve Omega
Thorne Pro-Resolving Mediators
Integrative Therapeutics Pure Omega HP
Integrative Therapeutics Pure Omega Liquid
Integrative Therapeutics Pure Omega Ultra HP
Pure Encapsulations PureNutrients EPA/DHA
Douglas Laboratories QÜELL® FISH OIL DHA Ultra SPM
Douglas Laboratories QUELL Fish Oil ® - EPA/DHA Plus D
Metagenics SPM Active
Thorne Super EPA
Thorne Super EPA NSF
Thorne Super EPA Pro
Vitabase Super Omega-3
Pure Encapsulations Ultra Pure Pack
Pure Encapsulations VisionPro EPA/DHA/GLA
Pure Encapsulations VisionPro EPA/DHA/GLA
Metagenics Wellness Essentials Active Daily Packs
Metagenics Wellness Essentials Brain Health Daily Packs
Metagenics Wellness Essentials® Daily Packs
Metagenics Wellness Essentials Healthy Balance Daily Packs
Metagenics Wellness Essentials Men's Vitality Daily Packs
Metagenics Wellness Essentials Women's Daily Packs
Metagenics Wellness Essentials Women's Prime Daily Packs
Designs For Health XanthOmega™ Krill Oil