Evidence supporting the use of: Flavanones
For the health condition: Alzheimer's Disease

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Flavanones are a subclass of flavonoids commonly found in citrus fruits such as oranges, lemons, and grapefruits. There is emerging scientific interest in the potential neuroprotective effects of flavanones due to their antioxidant, anti-inflammatory, and anti-amyloidogenic properties, all of which are relevant to the pathology of Alzheimer's Disease (AD). Preclinical studies—primarily in vitro and animal models—have demonstrated that certain flavanones like naringenin and hesperidin may inhibit the accumulation of beta-amyloid plaques, reduce oxidative stress, and modulate neuroinflammation. For example, a 2016 review in Frontiers in Aging Neuroscience discussed the putative mechanisms by which flavanones may confer neuroprotection, including the activation of signaling pathways involved in neuronal survival and synaptic plasticity. However, clinical data in humans remain limited. A few small-scale human trials have investigated the cognitive effects of citrus flavanones, indicating possible improvements in cognitive performance in healthy older adults, but these studies have not specifically targeted individuals with Alzheimer's Disease nor have they conclusively demonstrated disease-modifying effects. Therefore, while there is preclinical scientific rationale and early-phase clinical interest, robust evidence supporting the use of flavanones to treat or prevent Alzheimer's Disease in humans is currently lacking.

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amino acids
anthocyanins
ashwagandha
astaxanthin
berberine
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beta caryophyllene
bifidobacterium longum
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DPA (docosapentaenoic acid)
EPA (eicosapentaenoic acid)
epigallocatechin gallate (EGCG)
fisetin
fish oil
fish protein
flavonols
gamma tocopherol
genistein
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ginseng
glycerophosphocholine (GPC)
grape
green tea
hemp oil
hesperetin
hesperidin
huperzine A
l-carnitine
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l-serine
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lutein
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lycopene
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marine lipid
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naringin
niacinamide (vitamin B3)
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olive
omega-3 fatty acids
oyster mushroom
phenolic acids
phosphatidylcholine
phosphatidylserine
phospholipids
phytocannabinoids
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Products containing Flavanones

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