Evidence supporting the use of: Fungus
For the health condition: Alzheimer's Disease

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Several types of fungi, particularly medicinal mushrooms such as Hericium erinaceus (Lion's Mane), have been investigated for their potential to support or treat Alzheimer's Disease (AD). The scientific justification stems mainly from preclinical studies and a limited number of human trials. Lion's Mane contains compounds called hericenones and erinacines, which have been shown in laboratory and animal studies to stimulate the synthesis of nerve growth factor (NGF), a protein important for the survival and maintenance of neurons. Some small clinical studies have reported cognitive improvement in elderly adults with mild cognitive impairment following supplementation with Lion's Mane extract. However, these studies are generally small, of limited duration, and often lack robust controls.

Other fungi, such as Cordyceps and Ganoderma lucidum (Reishi), have also been studied for neuroprotective and anti-inflammatory effects, which could theoretically benefit AD patients. However, the evidence for these species is mainly limited to cell and animal models.

Currently, there is not enough high-quality clinical evidence to conclusively support the use of fungi as a treatment for Alzheimer's Disease. Most studies are preliminary, and large, well-controlled human trials are lacking. Therefore, while there is a scientific rationale and emerging evidence, the overall strength of support is modest (rated 2/5), and fungi should not be considered a substitute for evidence-based medical therapies for Alzheimer's Disease.

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acai berry
acetyl l-carnitine
akkermansia muciniphila
algal oil
alpha-linolenic acid (ALA)
amino acids
anthocyanins
ashwagandha
astaxanthin
berberine
berry flavor
beta caryophyllene
bifidobacterium longum
black garlic
black tea
blueberry
broccoli
butyrate triglyceride
caffeine
cannabis sativa oil
caprylic acid
catechins
Chinese salvia root
chokeberry
choline
cinnamon
citicoline
coenzyme Q10 (CoQ10)
turmeric
curcumin
cyclodextrin
d-alpha tocopherol
DHA (docosahexaeonic acid)
DPA (docosapentaenoic acid)
EPA (eicosapentaenoic acid)
epigallocatechin gallate (EGCG)
fisetin
fish oil
fish protein
flavonols
gamma tocopherol
genistein
ginkgo biloba
ginseng
glycerophosphocholine (GPC)
grape
green tea
hemp oil
hesperetin
hesperidin
huperzine A
l-carnitine
l-carnosine
l-serine
l-theanine
lentinula edodes mycelia
lion's mane
lutein
luteolin
lycopene
mackerel
magnesium
marine lipid
matcha
medium chain triglycerides (MCT)
melatonin
n-acetyl-cysteine (NAC)
naringin
niacinamide (vitamin B3)
nicotinamide riboside
olive
omega-3 fatty acids
oyster mushroom
phenolic acids
phosphatidylcholine
phosphatidylserine
phospholipids
phytocannabinoids
polygala root
pomegranate
pregnenolone
butyric acid
pyrroloquinoline disodium salt
quercetin
reishi mushroom
resveratrol
rhizome
rosemary
saffron
sage
SAMe (s-adenosyl-l-methionine disulfate p-toluensulfate)
sardines
selenium
sulforaphane glucosinolate
tocotrienols
trans-pterostilbene
tributyrin
ubiquinol
Urolithin A
vinpocetine
vitamin B
vitamin B12
vitamin C
vitamin D
vitamin D3
vitamin E
mulberry
β-nicotinamide mononucleotide (NMN)
gastrodia
tinospora cordifolia
lingzhi
morus
ferulic acid
cistanche
ganoderma
royal jelly
terpene lactones
polyphenols
hypothalamus
herbal blend (proprietary)
algae
cocoa
AMP-activated protein kinase (AMPK)
soy isoflavones
2-(carbamimidoyl-methyl-amino) ethoxyphosphonic acid
7,8-Dihydroxyflavone
7,14-Hydroxy-Docosapentaenoic Acid
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Acacetin
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Astragaloside
Ampelopsin
Aniracetam
Apocynin
Black Seed
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Butylphthalide
Beta-hydroxybutyrate
Bacopin
Baicalein
Benfotiamine
Basidiomycota
Brahmi
Bacopa
Bifidobacteria
bacoside
Baicalin
Caffeic Acid
Centrophenoxine
Camellia sinensis
Caryophyllene
Cinnamomum
Crocin
Carnosine
Catalpol
Cyanidin
Curcuminoid
Curcumen
Chinese Ligustrum berry
Creatine
Curcuma
C-Phycocyanin
Convolvulus prostratus
Crocetin
Cytidine
Carnosic acid
Cannabigerol
Docosahexaenoic Acid
Decursin
Dihydrolipoic Acid
epicatechin
Ellagic Acid
Ergothioneine
Eicosapentaenoic Acid
Estrogen
Ecklonia
Flavonoids
Fish
Fatty acids
Flavonones
Ketone Salts
walnut

Products containing Fungus

We currently have no products on Vitabase that contain this ingredient.