Evidence supporting the use of: Ginkgoside
For the health condition: Alzheimer's Disease

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Ginkgoside refers to the active compounds found in Ginkgo biloba, a plant extract that has been traditionally used in Chinese medicine. Over recent decades, Ginkgo biloba extract (notably standardized extracts like EGb 761, which contain defined amounts of ginkgosides) has been studied for potential cognitive benefits, including in Alzheimer’s disease (AD). The proposed mechanisms include antioxidant activity, enhancement of cerebral blood flow, modulation of neurotransmitter systems, and neuroprotective effects. Some randomized controlled trials and meta-analyses have found that Ginkgo biloba extract may have modest, short-term benefits for cognitive function and activities of daily living in people with mild to moderate dementia, including AD. However, other well-designed studies have failed to show significant benefits compared to placebo. The 2016 Cochrane review concluded that there is some evidence of improvement in cognition, but the effect size is small and clinical relevance is uncertain. Major clinical guidelines generally do not recommend Ginkgo as a standard treatment for AD, citing inconsistent results and methodological limitations in the studies. Safety concerns (such as bleeding risk) are also noted. In summary, while there is some scientific investigation and modest evidence supporting the use of ginkgosides for AD, overall support is weak and not robustly validated.

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astaxanthin
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fish oil
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flavonols
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glycerophosphocholine (GPC)
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hemp oil
hesperetin
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Products containing Ginkgoside

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