Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Grapes, particularly their skins and seeds, are rich in polyphenolic compounds such as resveratrol and flavonoids, which have been studied for their potential neuroprotective effects relevant to Alzheimer's Disease (AD). Scientific interest in grapes for AD support stems from these bioactive components' antioxidant and anti-inflammatory properties, and their capacity to modulate amyloid-beta (Aβ) aggregation and tau pathology, both hallmarks of Alzheimer's pathology. Preclinical studies in cell cultures and animal models have shown that grape-derived polyphenols can reduce oxidative stress, inhibit Aβ fibril formation, and improve cognitive function. For example, resveratrol has been demonstrated to cross the blood-brain barrier and attenuate neurodegenerative processes in some animal studies.

However, clinical evidence in humans is limited and mixed. Some small-scale randomized controlled trials have suggested modest cognitive benefits from grape juice or resveratrol supplementation in older adults with mild cognitive impairment or early AD, but these studies often suffer from small sample sizes, short durations, and variable methodologies. Larger and more robust clinical trials are needed to conclusively determine efficacy. As a result, while there is scientific rationale and some preliminary evidence to support the use of grape-derived compounds for Alzheimer's Disease, the current level of evidence is best described as limited (rated 2 out of 5). Grapes and their extracts should not be considered a primary or standalone treatment for AD, but may be used as part of a healthy diet that could support brain health.

More about grape
More about Alzheimer's Disease

Other ingredients used for Alzheimer's Disease

Other health conditions supported by grape

Products containing grape

Vitabase Active Man's Formula
Pure Encapsulations Athletic Nutrients
Douglas Laboratories Berberine Balance
Designs For Health BergaVin™ 60 capsules
Vitabase Bilberry Extract Plus
Metagenics Ceralin® Forte
Vitabase Cholesterol Support
Pure Encapsulations CurcumaSorb Mind
Designs For Health Detox Antiox™
Integrative Therapeutics Detoxication Factors
Integrative Therapeutics Detoxication Factors
Designs For Health Detoxification Support Packets
Pure Encapsulations DopaPlus
Integrative Therapeutics EHB
Designs For Health EssentiaGreens™
Douglas Laboratories Glucosamine + MSM Forte ™
Douglas Laboratories Glucosamine Plus ™
Pure Encapsulations Grape Pip 500 mg
Vitabase Grape Seed Extract
Thorne Grape Seed Extract O.P.C.-100
Designs For Health Grape Seed Supreme™
Douglas Laboratories Hair Growth+
Pure Encapsulations Hair/Skin/Nails Ultra
Designs For Health HTN Supreme™
Douglas Laboratories Juvenon Pro Cognitive
Klean Athlete Klean Focus®
Vitabase Life's Essentials Plus
Pure Encapsulations Macular Support Formula
Pure Encapsulations Macular Support Formula
Thorne MediClear Plus
Douglas Laboratories Optimized Curcumin With Neurophenol™
Designs For Health PaleoCleanse Plus™
Designs For Health PaleoCleanse Plus™
Designs For Health PaleoCleanse Plus™ Detox Program
Designs For Health PaleoCleanse Plus™Chocolate Detox Kit
Designs For Health PaleoGreens®
Designs For Health PaleoGreens®
Designs For Health PaleoReds®
Designs For Health PhytoBiome™
Metagenics PhytoMulti™ Multivitamin
Metagenics PhytoMulti With Iron
Metagenics PhytoMulti Without Iron
Metagenics PhytoMultivitamin
Designs For Health Plant Protein Cleanse Plus™ 570g
Pure Encapsulations Polyphenol Nutrients
Pure Encapsulations Polyphenol Nutrients
Designs For Health Primal Multi™
Pure Encapsulations Resveratrol Extra
Pure Encapsulations Resveratrol Extra
Integrative Therapeutics Resveratrol Ultra HP 175mg
Designs For Health Senolytic Synergy
Designs For Health Ultimate Antiox Full Spectrum
Douglas Laboratories Ultra Benfotiamine
Douglas Laboratories Ultra Preventive
Douglas Laboratories Ultra Preventive
Douglas Laboratories Ultra Preventive ®-EZ Swallow
Douglas Laboratories Ultra Preventive® X
Pure Encapsulations Ultra Pure Pack
Pure Encapsulations Uric Acid Formula
Douglas Laboratories Uro-Pro ®
Pure Encapsulations Vascular Relax
Designs For Health Vessel Forte™
Vitabase Vision Support
Metagenics Wellness Essentials Active Daily Packs
Metagenics Wellness Essentials Brain Health Daily Packs
Metagenics Wellness Essentials® Daily Packs
Metagenics Wellness Essentials Healthy Balance Daily Packs
Metagenics Wellness Essentials Men's Vitality Daily Packs
Metagenics Wellness Essentials Women's Daily Packs
Metagenics Wellness Essentials Women's Prime Daily Packs
Pure Encapsulations Women's Nutrients