Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Magnesium has been investigated for its potential role in supporting cognitive function and possibly modifying the course of Alzheimer's Disease (AD). While magnesium is not a standard, FDA-approved treatment for AD, there is a growing body of scientific research suggesting its involvement in brain health. Magnesium is crucial for normal neuronal function, and deficiencies can negatively impact synaptic plasticity and cognitive processes. Preclinical studies in animal models have demonstrated that magnesium supplementation can enhance synaptic density and improve learning and memory, potentially by modulating NMDA receptor activity and reducing neuroinflammation. In humans, observational studies have found that lower serum magnesium levels may be associated with increased risk of cognitive decline and dementia, including AD. However, interventional trials in humans are limited and have yielded mixed results, with some small studies suggesting possible cognitive benefits and others finding no significant effect. The evidence is not yet robust enough to recommend magnesium supplementation as a specific therapy for AD, but it is considered an area of active research. In summary, while there is scientific interest and some early evidence supporting a role for magnesium in brain health and possibly in reducing AD risk, the clinical evidence remains inconclusive. Thus, magnesium's use in AD is supported by preliminary scientific rationale rather than strong clinical validation.

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