Evidence supporting the use of: Oleuropein
For the health condition: Alzheimer's Disease

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Oleuropein is a phenolic compound found in olives and olive leaves, and has garnered scientific interest for its potential neuroprotective effects, including in the context of Alzheimer's Disease (AD). Preclinical studies have shown that oleuropein can reduce the accumulation of beta-amyloid plaques, a hallmark of AD pathology, and exert antioxidant and anti-inflammatory effects in neuronal tissue. For example, animal studies have demonstrated that oleuropein aglycone administration can improve cognitive performance and reduce amyloid aggregation in mouse models of AD (Grossi et al., 2013; Pantano et al., 2017). Additionally, in vitro research indicates that oleuropein may modulate autophagy and protect neurons from oxidative stress-induced apoptosis.

However, despite these promising preclinical findings, there is a lack of robust human clinical trials demonstrating efficacy of oleuropein for treating or preventing Alzheimer's Disease. Most evidence is limited to laboratory and animal studies, and clinical validation in humans is currently insufficient. Therefore, while the scientific rationale exists based on mechanistic and animal model data, the overall strength of evidence supporting oleuropein’s use in AD remains preliminary. Further, large-scale, well-designed clinical trials are necessary to establish its safety and efficacy for this indication.

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ashwagandha
astaxanthin
berberine
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beta caryophyllene
bifidobacterium longum
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caprylic acid
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chokeberry
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citicoline
coenzyme Q10 (CoQ10)
turmeric
curcumin
cyclodextrin
d-alpha tocopherol
DHA (docosahexaeonic acid)
DPA (docosapentaenoic acid)
EPA (eicosapentaenoic acid)
epigallocatechin gallate (EGCG)
fisetin
fish oil
fish protein
flavonols
gamma tocopherol
genistein
ginkgo biloba
ginseng
glycerophosphocholine (GPC)
grape
green tea
hemp oil
hesperetin
hesperidin
huperzine A
l-carnitine
L-carnosine
L-serine
L-theanine
lentinula edodes mycelia
lion's mane
lutein
luteolin
lycopene
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magnesium
marine lipid
matcha
medium chain triglycerides (MCT)
melatonin
n-acetyl-cysteine (NAC)
naringin
niacinamide (Vitamin B3)
nicotinamide riboside
olive
omega-3 fatty acids
oyster mushroom
phenolic compounds
phosphatidylcholine
phosphatidylserine
phospholipids
phytocannabinoids
polygala root
pomegranate
pregnenolone
butyric acid
pyrroloquinoline disodium salt
quercetin
reishi mushroom
resveratrol
rhizome
rosemary
saffron
sage
SAMe (s-adenosyl-l-methionine disulfate p-toluensulfate)
sardines
selenium
sulforaphane glucosinolate
tocotrienols
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tributyrin
ubiquinol
Urolithin A
vinpocetine
vitamin B
vitamin B12
vitamin C
vitamin D
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vitamin E
mulberry
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gastrodia
tinospora cordifolia
lingzhi
morus
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ganoderma
royal jelly
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hypothalamus
herbal blend (proprietary)
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Products containing Oleuropein

We currently have no products on Vitabase that contain this ingredient.