Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Olive, particularly in the form of extra virgin olive oil (EVOO), has garnered scientific interest for its potential role in supporting cognitive health and possibly mitigating the progression of Alzheimer’s Disease (AD). This interest is largely based on epidemiological studies of the Mediterranean diet, which is rich in olive oil and has been associated with a reduced risk of cognitive decline and Alzheimer's. The proposed mechanisms involve the high content of monounsaturated fatty acids (mainly oleic acid) and bioactive polyphenols (such as oleuropein and hydroxytyrosol) in olive oil, which exhibit antioxidant and anti-inflammatory properties. These compounds may help reduce oxidative stress, neuroinflammation, and amyloid-beta plaque formation—hallmarks of AD pathology. Preclinical studies in animal models have shown that EVOO supplementation can improve cognitive function and reduce AD-related pathology. A limited number of small-scale human studies and clinical trials have also reported cognitive benefits in older adults consuming a Mediterranean diet supplemented with olive oil. However, while these findings are promising, the evidence is not yet robust; most human studies are observational, and randomized controlled trials specifically targeting olive oil's effect on Alzheimer’s risk or progression are still limited. In summary, the use of olive oil for Alzheimer’s is supported by emerging scientific evidence, but direct, high-quality clinical validation remains insufficient. Thus, while promising, olive oil should be considered a supportive dietary component rather than a proven treatment for Alzheimer’s Disease.

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