Evidence supporting the use of: Piperine
For the health condition: Alzheimer's Disease

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Piperine, an alkaloid found in black pepper (Piper nigrum), has attracted some scientific interest as a potential supportive agent in Alzheimer's Disease (AD). Preclinical studies, primarily in animal models and in vitro experiments, suggest that piperine exhibits neuroprotective effects. Proposed mechanisms include antioxidant activity, inhibition of acetylcholinesterase (an enzyme that breaks down acetylcholine, a key neurotransmitter diminished in AD), and anti-inflammatory properties. Piperine has also been shown to modulate amyloid-beta aggregation and deposition in some rodent models, a hallmark pathology of Alzheimer's Disease.

Despite these promising findings in laboratory settings, evidence in humans is lacking. No large-scale, high-quality clinical trials have demonstrated clear benefits of piperine supplementation in AD patients. Most of the evidence remains preliminary, and translation from animal models to human disease is uncertain. Furthermore, safety and effective dosing in humans with AD have not been well established. Therefore, while there is some scientific basis for further investigation, current support for piperine’s use in Alzheimer’s Disease is limited and not yet robust enough for clinical recommendations.

In summary, piperine is being researched for its potential neuroprotective and anti-Alzheimer’s effects, but the evidence is currently insufficient to justify its routine use for this purpose outside of experimental settings.

More about Piperine
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Other ingredients used for Alzheimer's Disease

acai berry
acetyl l-carnitine
akkermansia muciniphila
algal oil
alpha-linolenic acid (ALA)
amino acids
anthocyanins
ashwagandha
astaxanthin
berberine
berry flavor
beta caryophyllene
bifidobacterium longum
black garlic
black tea
blueberry
broccoli
butyrate triglyceride
caffeine
cannabis sativa oil
caprylic acid
catechins
Chinese salvia root
chokeberry
choline
cinnamon
citicoline
coenzyme Q10 (CoQ10)
turmeric
curcumin
cyclodextrin
d-alpha tocopherol
DHA (docosahexaeonic acid)
DPA (docosapentaenoic acid)
EPA (eicosapentaenoic acid)
epigallocatechin gallate (EGCG)
fisetin
fish oil
fish protein
flavonols
gamma tocopherol
genistein
ginkgo biloba
ginseng
glycerophosphocholine (GPC)
grape
green tea
hemp oil
hesperetin
hesperidin
huperzine A
l-carnitine
l-carnosine
l-serine
l-theanine
lentinula edodes mycelia
lion's mane
lutein
luteolin
lycopene
mackerel
magnesium
marine lipid
matcha
medium chain triglycerides (MCT)
melatonin
n-acetyl-cysteine (NAC)
naringin
niacinamide (vitamin B3)
nicotinamide riboside
olive
omega-3 fatty acids
oyster mushroom
phenolic acids
phosphatidylcholine
phosphatidylserine
phospholipids
phytocannabinoids
polygala root
pomegranate
pregnenolone
butyric acid
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quercetin
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resveratrol
rhizome
rosemary
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sardines
selenium
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tocotrienols
trans-pterostilbene
tributyrin
ubiquinol
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vitamin B
vitamin B12
vitamin C
vitamin D
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vitamin E
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epicatechin
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Ergothioneine
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Products containing Piperine

We currently have no products on Vitabase that contain this ingredient.