Evidence supporting the use of: Polyunsaturated Fat
For the health condition: Alzheimer's Disease

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Polyunsaturated fats (PUFAs), particularly omega-3 fatty acids like docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA), have been investigated for their potential role in supporting cognitive function and slowing the progression of Alzheimer's disease (AD). The scientific rationale stems from the role of PUFAs in maintaining neuronal membrane integrity, modulating inflammation, and supporting synaptic function—all of which are relevant to neurodegeneration in AD.

Epidemiological studies suggest that higher dietary intake of omega-3 PUFAs is associated with a reduced risk of cognitive decline and Alzheimer's disease. Some observational studies have shown that individuals with higher plasma levels of DHA have a lower risk of developing AD. However, randomized controlled trials (RCTs) on PUFA supplementation in people with existing AD have largely produced mixed or modest results. Some trials report small benefits in slowing cognitive decline, especially in those with mild cognitive impairment or in early stages of the disease, but others find no significant effect.

A 2020 Cochrane review concluded that omega-3 supplementation does not significantly benefit cognitive function in people with mild to moderate AD, but may have a potential preventive effect before disease onset. Overall, the evidence supports a biological plausibility and some potential benefit, but does not strongly validate routine PUFA use for treating established Alzheimer's disease.

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acai berry
acetyl l-carnitine
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alpha-linolenic acid (ALA)
amino acids
anthocyanins
ashwagandha
astaxanthin
berberine
berry flavor
beta caryophyllene
bifidobacterium longum
black garlic
black tea
blueberry
broccoli
butyrate triglyceride
caffeine
cannabis sativa oil
caprylic acid
catechins
Chinese salvia root
chokeberry
choline
cinnamon
citicoline
coenzyme Q10 (CoQ10)
turmeric
curcumin
cyclodextrin
d-alpha tocopherol
DHA (docosahexaeonic acid)
DPA (docosapentaenoic acid)
EPA (eicosapentaenoic acid)
epigallocatechin gallate (EGCG)
fisetin
fish oil
fish protein
flavonols
gamma tocopherol
genistein
ginkgo biloba
ginseng
glycerophosphocholine (GPC)
grape
green tea
hemp oil
hesperetin
hesperidin
huperzine A
l-carnitine
l-carnosine
l-serine
l-theanine
lentinula edodes mycelia
lion's mane
lutein
luteolin
lycopene
mackerel
magnesium
marine lipid
matcha
medium chain triglycerides (MCT)
melatonin
n-acetyl-cysteine (NAC)
naringin
niacinamide (vitamin B3)
nicotinamide riboside
olive
omega-3 fatty acids
oyster mushroom
phenolic acids
phosphatidylcholine
phosphatidylserine
phospholipids
phytocannabinoids
polygala root
pomegranate
pregnenolone
butyric acid
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quercetin
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resveratrol
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rosemary
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epicatechin
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Ergothioneine
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Products containing Polyunsaturated Fat

We currently have no products on Vitabase that contain this ingredient.