Evidence supporting the use of: Pycnogenol
For the health condition: Alzheimer's Disease

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Pycnogenol, an extract from the bark of the French maritime pine (Pinus pinaster), has been researched for its antioxidant and anti-inflammatory properties, which are mechanisms relevant to neurodegenerative diseases like Alzheimer's Disease (AD). Preclinical studies have demonstrated that Pycnogenol may reduce oxidative stress, inhibit amyloid-beta aggregation, and improve cerebral blood flow in animal models of AD. These effects have generated interest in its potential as a supplement for cognitive support and neuroprotection.

However, clinical evidence in humans is limited. A few small human trials and observational studies have reported modest benefits of Pycnogenol supplementation on cognitive function, memory, and attention in elderly individuals and those with mild cognitive impairment. For example, a 2008 study found some cognitive improvement in elderly subjects after Pycnogenol supplementation, but these studies were not specific to Alzheimer's patients and had methodological limitations, such as small sample sizes and short durations. There are no large-scale, high-quality randomized controlled trials directly assessing Pycnogenol for the treatment or prevention of Alzheimer's Disease.

In summary, while there is a scientific rationale and some preliminary evidence suggesting potential benefits of Pycnogenol for cognitive health, the current clinical evidence specific to Alzheimer's Disease is weak. More rigorous research is needed before Pycnogenol can be recommended as a treatment or adjunctive therapy for Alzheimer's Disease.

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Products containing Pycnogenol

We currently have no products on Vitabase that contain this ingredient.