Evidence supporting the use of: Pyrroloquinoline quinone
For the health condition: Alzheimer's Disease

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Pyrroloquinoline Quinone (PQQ) is a redox cofactor found in foods and sometimes marketed as a dietary supplement for cognitive health, including Alzheimer’s Disease (AD). The scientific interest in PQQ for AD largely stems from its antioxidant properties and its role in mitochondrial biogenesis, which are both relevant given that oxidative stress and mitochondrial dysfunction are implicated in the pathogenesis of AD. Preclinical studies in animal models have shown that PQQ supplementation can decrease oxidative damage, reduce amyloid-beta accumulation, and improve memory performance. For instance, several rodent studies demonstrated that PQQ could protect against neurotoxicity induced by amyloid-beta peptides, which are central to AD pathology. However, robust clinical evidence in humans is lacking. A small number of pilot studies in humans have explored PQQ’s effects on cognitive function, but these were generally not specific to AD patients and often combined PQQ with other compounds (such as CoQ10), making it difficult to attribute observed effects solely to PQQ. No large, well-controlled clinical trials specifically studying PQQ in Alzheimer’s patients have been published as of June 2024. In summary, while there is scientific rationale and some promising preclinical evidence for PQQ’s potential neuroprotective role, the clinical evidence in AD is sparse and preliminary, warranting a low evidence rating.

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Products containing pyrroloquinoline quinone

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