Evidence supporting the use of: Rosmarinic acid
For the health condition: Alzheimer's Disease

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Rosmarinic acid, a polyphenolic compound found in herbs like rosemary and perilla, has been investigated for its potential neuroprotective effects, including possible benefits in Alzheimer's disease (AD). Preclinical studies (cell and animal models) suggest that rosmarinic acid may exert anti-inflammatory, antioxidant, and anti-amyloidogenic activities. These mechanisms are relevant to Alzheimer's pathology, as oxidative stress, neuroinflammation, and amyloid-beta aggregation are key contributors to disease progression. For example, research has shown that rosmarinic acid can inhibit amyloid-beta aggregation and reduce neurotoxicity in vitro. Animal studies have reported improved cognitive performance and reduced amyloid plaque deposition when treated with rosmarinic acid.

However, clinical evidence in humans is lacking. Most of the supportive data come from laboratory and animal research, with only limited evidence from human trials, if any. No large, randomized controlled trials have conclusively demonstrated efficacy or safety of rosmarinic acid supplementation in Alzheimer's patients. As such, while the mechanistic rationale and early experimental findings are promising, translation to clinical use remains unproven.

In summary, the use of rosmarinic acid for Alzheimer's disease is supported primarily by preclinical scientific evidence, but currently lacks strong clinical validation. Its rating is therefore low (2/5) until more human studies are available.

More about rosmarinic acid
More about Alzheimer's Disease

Other ingredients used for Alzheimer's Disease

2-(carbamimidoyl-methyl-amino) ethoxyphosphonic acid
7,14-Hydroxy-Docosapentaenoic Acid
7,8-Dihydroxyflavone
Acacetin
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Cinnamomum
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Convolvulus prostratus
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Curcuma
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DHA (docosahexaenoic acid)
dihydrolipoic acid
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DPA (docosapentaenoic acid)
Ecklonia
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EPA (eicosapentaenoic acid)
epicatechin
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ergothioneine
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fish
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flavanols
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Products containing rosmarinic acid

We currently have no products on Vitabase that contain this ingredient.