Evidence supporting the use of: Salidrosides
For the health condition: Alzheimer's Disease

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Salidroside is a bioactive compound derived from Rhodiola rosea, a traditional medicinal plant. Its use for Alzheimer's Disease (AD) is primarily supported by preclinical scientific studies, rather than established traditional use for dementia or Alzheimer's specifically. Research conducted in cell cultures and animal models has shown that salidroside possesses neuroprotective, anti-inflammatory, and antioxidant properties. These attributes are believed to be beneficial in the context of AD, a disorder characterized by neuronal loss, neuroinflammation, oxidative stress, and abnormal protein aggregation.

Notably, studies in mice have demonstrated that salidroside administration can reduce cognitive deficits, decrease β-amyloid deposition, and mitigate oxidative damage in the brain. Mechanistic research suggests it may activate cellular pathways (such as the PI3K/Akt and Nrf2 pathways) that promote neuronal survival and resilience against toxic insults associated with Alzheimer's pathology.

However, it is important to highlight that no clinical trials in humans have yet confirmed these benefits for Alzheimer's Disease. Thus, while the evidence is promising in laboratory settings, the translation to human efficacy remains unproven. Its use for AD is based on early-stage scientific validation rather than robust clinical evidence or a long-standing traditional practice for this specific indication.

More about Salidrosides
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flavonols
gamma tocopherol
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glycerophosphocholine (GPC)
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hemp oil
hesperetin
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Products containing Salidrosides

We currently have no products on Vitabase that contain this ingredient.