Evidence supporting the use of: Schizochytrium Oil
For the health condition: Alzheimer's Disease
Synopsis
Source of validity: Scientific
Rating (out of 5): 2
Schizochytrium oil is a rich, vegan source of the long-chain omega-3 fatty acid docosahexaenoic acid (DHA). There is scientific interest in DHA because it is a major component of neuronal membranes and plays a role in brain function. Epidemiological studies have suggested that higher dietary intake of omega-3 fatty acids, including DHA, may be associated with a reduced risk of cognitive decline and Alzheimer’s disease (AD). Some randomized controlled trials have investigated the effects of DHA supplementation (including from Schizochytrium oil) in Alzheimer’s patients or in those at risk. However, results have been mixed. For example, the large ADCS DHA trial (JAMA, 2010) using algal DHA (from Schizochytrium) found no significant benefit in mild to moderate AD patients, though some subgroup analyses suggested possible slowing of cognitive decline in those without the APOE4 gene. Other trials in mild cognitive impairment or healthy older adults have shown modest benefits, but consistency and effect size are limited. The main scientific rationale for using Schizochytrium oil is thus based on its DHA content and the biological plausibility of DHA supporting brain health. However, current evidence does not robustly support its efficacy as a treatment for Alzheimer’s disease. Therefore, while its use is grounded in scientific rationale and is under study, the overall quality and consistency of evidence for treating or preventing Alzheimer’s disease is relatively low (rated 2/5).
More about Schizochytrium Oil
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Other ingredients used for Alzheimer's Disease
2-(carbamimidoyl-methyl-amino) ethoxyphosphonic acid7,14-Hydroxy-Docosapentaenoic Acid
7,8-Dihydroxyflavone
Acacetin
Acai berry
Acetyl L-carnitine
Acetylcholine
Agmatine
Akkermansia muciniphila
Algae
algal oil
alpha-linolenic acid (ALA)
alpha-lipoic acid
amentoflavone
amino acids
AMP-activated protein kinase (AMPK)
ampelopsin
aniracetam
anserine
anthocyanins
apigenin
apocynin
Aronia melanocarpa
ashwagandha
astaxanthin
astragaloside
avocado
Bacopa
Bacopin
bacoside
baicalein
baicalin
Basidiomycota
benfotiamine
berberine
beta caryophyllene
beta-hydroxybutyrate
Bifidobacteria
Bifidobacterium longum
bilobalide
black garlic
black seed
black tea
blueberry
brahmi
broccoli
butylphthalide
butyrate triglyceride
butyric acid
C-phycocyanin
caffeic Acid
caffeine
Camellia sinensis
cannabigerol
Cannabis sativa oil
caprylic acid
carnosic acid
Carnosine
caryophyllene
catalpol
catechins
centrophenoxine
Chinese Ligustrum berry
Chinese salvia root
chokeberry
choline
Cinnamomum
cinnamon
cistanche
citicoline
cocoa
coenzyme Q10 (CoQ10)
Convolvulus prostratus
creatine
crocetin
crocin
Curcuma
curcumen
curcumin
Curcuminoid
cyanidin
cyclodextrin
cytidine
d-alpha tocopherol
decursin
DHA (docosahexaenoic acid)
dihydrolipoic acid
docosahexaenoic Acid
DPA (docosapentaenoic acid)
Ecklonia
eicosapentaenoic acid
ellagic acid
EPA (eicosapentaenoic acid)
epicatechin
epigallocatechin gallate (EGCG)
ergothioneine
estrogen
fatty acids
ferulic acid
fisetin
fish
fish oil
fish protein
flavanols
flavanones
flavans
flavones
flavonoids
flavonols
flavonones
fo-ti
fungus
galantamine
gallate
gallic acid
gamma tocopherol
ganoderma
garcinol
gastrodia
gastrodin
genistein
ginkgetin
ginkgo biloba
ginkgo flavone glycoside
ginkgoheteroside
ginkgolides
Ginkgoside
ginseng
Ginsenosides
Glucoraphanin
glycerophosphocholine (GPC)
grape
green tea
Gypenoside
hemp
hemp oil
herbal blend (proprietary)
Hericenones
hericium mushroom
hesperetin
hesperidin
Homotaurine
Honokiol
huperzine A
hydroxytyrosol
Hyperoside
icariin
iridoids
isoliquiritigenin
isovitexin
Kaempferol
ketone salts
l-carnitine
L-carnosine
L-serine
L-theanine
Lentinula edodes mycelia
lingzhi
lion's mane
lipids
lutein
luteolin
Lycium
lycopene
magnesium
magnolol
malvidin
mangiferin
Marine fat
Marine lipid
Maslinic acid
Matcha
medium chain triglycerides (MCT)
Melatonin
Methoxylated flavones
Methylcobalamin
Monoterpenes
Monounsaturated fat
Morus
Mulberroside A
Mulberry
Myricetin
Myricitrin
N-acetyl-cysteine (NAC)
NADH
Naringenin
Naringin
Nervonic acid
Niacinamide (vitamin B3)
nicotinamide riboside
Nigella seed
Nobiletin
Norvaline
Oleuropein
olive
omega-3 fatty acids
Osthole
oyster mushroom
paeoniflorin
Pentacyclic triterpenoids
Peptides
phenolic compounds
phosphatidylcholine
phosphatidylserine
phospholipids
Phycocyanin
phytocannabinoids
Phytoestrogens
Piperine
Polydatin
Polygala
polygala root
polymethoxylated flavones
polyphenols
polysaccharides
polyunsaturated fat
pomegranate
pregnenolone
punicalagins
Pycnogenol
pyrroloquinoline disodium salt
pyrroloquinoline quinone
quercetin
reishi mushroom
resveratrol
rhizome
rosemary
rosmarinic acid
royal jelly
S-allylcysteine
saffron
Safranal
sage
Salidroside
Salmon Oil
Salvianolic acid
SAMe (S-adenosyl-L-methionine disulfate p-toluensulfate)
Sarcosine
Schisandrins
Schizochytrium
Schizochytrium Oil
selenium
Selenocysteine
Shankhpushpi
Shilajit
Shogaol
Solanaceae
Soy
soy isoflavones
Stilbenoid
Sulforaphane
sulforaphane glucosinolate
Syringic acid
Tangeretin
Taurine
Taxifolin
terpene lactones
Terpenoids
Theaflavin
Tinospora cordifolia
tocotrienols
Trans-pterostilbene
Trehalose
Tremella
tributyrin
Triterpenes
Tumerone
turmeric
Turmerones
ubiquinol
Uncaria
Uridine
Urolithin A
Ursolic Acid
Vinpocetine
vitamin B
vitamin B12
vitamin C
vitamin D
vitamin D3
vitamin E
Walnut
Withanolides
Wogonin
Xanthohumol
Xanthophyll
Xylaria nigripes
β-nicotinamide mononucleotide (NMN)