Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Tauroursodeoxycholic acid (TUDCA) is a bile acid derivative that has gained interest for its potential neuroprotective properties in neurodegenerative disorders, including Alzheimer's disease (AD). The scientific rationale for its use is based primarily on preclinical studies. TUDCA has demonstrated the ability to reduce endoplasmic reticulum stress, inhibit apoptosis, and protect mitochondrial function in cellular and animal models of neurodegeneration. Several studies in transgenic mouse models of Alzheimer’s disease have shown that TUDCA administration can reduce amyloid-beta aggregation, decrease neuronal loss, and improve cognitive performance. For example, a 2004 study in Journal of Neuroscience reported that TUDCA prevented apoptosis and attenuated amyloid pathology in an AD mouse model.

Despite these promising preclinical findings, high-quality human clinical trials evaluating the efficacy and safety of TUDCA in Alzheimer's disease are lacking. No large-scale, peer-reviewed randomized controlled trials have been published as of 2024. As such, the evidence supporting its use in AD remains preliminary, and its clinical utility has not been established. Current scientific validation is therefore limited to animal and cell-based studies, warranting a modest evidence rating of 2 out of 5. Further research, particularly well-designed human trials, is necessary before TUDCA can be recommended as a treatment for Alzheimer’s disease.

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Other ingredients used for Alzheimer's Disease

acai berry
acetyl l-carnitine
akkermansia muciniphila
algal oil
alpha-linolenic acid (ALA)
amino acids
anthocyanins
ashwagandha
astaxanthin
berberine
berry flavor
beta caryophyllene
bifidobacterium longum
black garlic
black tea
blueberry
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butyrate triglyceride
caffeine
cannabis sativa oil
caprylic acid
catechins
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chokeberry
choline
cinnamon
citicoline
coenzyme Q10 (CoQ10)
turmeric
curcumin
cyclodextrin
d-alpha tocopherol
DHA (docosahexaeonic acid)
DPA (docosapentaenoic acid)
EPA (eicosapentaenoic acid)
epigallocatechin gallate (EGCG)
fisetin
fish oil
fish protein
flavonols
gamma tocopherol
genistein
ginkgo biloba
ginseng
glycerophosphocholine (GPC)
grape
green tea
hemp oil
hesperetin
hesperidin
huperzine A
l-carnitine
l-carnosine
l-serine
l-theanine
lentinula edodes mycelia
lion's mane
lutein
luteolin
lycopene
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magnesium
marine lipid
matcha
medium chain triglycerides (MCT)
melatonin
n-acetyl-cysteine (NAC)
naringin
niacinamide (vitamin B3)
nicotinamide riboside
olive
omega-3 fatty acids
oyster mushroom
phenolic acids
phosphatidylcholine
phosphatidylserine
phospholipids
phytocannabinoids
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pomegranate
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butyric acid
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quercetin
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resveratrol
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Crocetin
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epicatechin
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Ergothioneine
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Estrogen
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Other health conditions supported by Tauroursodeoxycholic Acid

Alzheimer's Disease
Cirrhosis of the Liver
Fatty Liver Disease
Hepatitis
Liver Detoxification
Parkinson's Disease

Products containing Tauroursodeoxycholic Acid

We currently have no products on Vitabase that contain this ingredient.