Evidence supporting the use of: Tetrahydrocannabinol
For the health condition: Alzheimer's Disease

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Tetrahydrocannabinol (THC), the main psychoactive compound in cannabis, has attracted research interest for its potential effects on Alzheimer's Disease (AD). Preclinical studies, especially in vitro and animal models, indicate that THC may reduce the accumulation of amyloid-beta plaques—a hallmark of AD—by inhibiting the enzyme acetylcholinesterase and reducing amyloid aggregation. THC has also been shown to have anti-inflammatory and neuroprotective properties, which could theoretically help slow neurodegeneration.

However, robust clinical evidence in humans is lacking. Most published human studies have small sample sizes and focus on symptomatic relief—such as agitation, aggression, and appetite loss in advanced AD—rather than disease modification. Some small trials report modest improvement in behavioral symptoms, but results are inconsistent, and side effects such as sedation, confusion, and increased fall risk are concerns, especially in elderly populations.

Major medical organizations generally do not recommend THC as a treatment for Alzheimer's Disease due to insufficient high-quality evidence. Current research is ongoing, but as of now, the scientific validation is limited, and the evidence supporting THC’s use in AD is weak to moderate at best.

More about Tetrahydrocannabinol
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alpha-linolenic acid (ALA)
amino acids
anthocyanins
ashwagandha
astaxanthin
berberine
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beta caryophyllene
bifidobacterium longum
black garlic
black tea
blueberry
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butyrate triglyceride
caffeine
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citicoline
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curcumin
cyclodextrin
d-alpha tocopherol
DHA (docosahexaeonic acid)
DPA (docosapentaenoic acid)
EPA (eicosapentaenoic acid)
epigallocatechin gallate (EGCG)
fisetin
fish oil
fish protein
flavonols
gamma tocopherol
genistein
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ginseng
glycerophosphocholine (GPC)
grape
green tea
hemp oil
hesperetin
hesperidin
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l-carnitine
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l-serine
l-theanine
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lutein
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lycopene
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matcha
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naringin
niacinamide (vitamin B3)
nicotinamide riboside
olive
omega-3 fatty acids
oyster mushroom
phenolic acids
phosphatidylcholine
phosphatidylserine
phospholipids
phytocannabinoids
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Products containing Tetrahydrocannabinol

We currently have no products on Vitabase that contain this ingredient.