Evidence supporting the use of: Uncaria rhynchophylla
For the health condition: Alzheimer's Disease

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Uncaria rhynchophylla, commonly known as Gou Teng, is a traditional Chinese medicinal herb that has been investigated for its potential neuroprotective effects, including applications in Alzheimer's disease (AD). Preclinical studies, mostly in vitro and in animal models, have shown that extracts from Uncaria rhynchophylla contain alkaloids, such as rhynchophylline, which may exert neuroprotective effects through multiple mechanisms. These include inhibition of beta-amyloid-induced neurotoxicity, reduction of tau phosphorylation, antioxidant activity, and modulation of neurotransmitter systems and calcium channels. Notably, some studies have demonstrated that Uncaria rhynchophylla extract can reduce cognitive deficits and neuropathological changes in AD mouse models. For example, a 2010 study published in "Neuroscience Letters" reported that Uncaria rhynchophylla extract attenuated learning and memory impairment in an amyloid-beta-induced Alzheimer’s model in rats. However, there is a lack of robust clinical evidence in humans; most available data are preclinical or derived from traditional Chinese medicine formulations (such as Yokukansan) that include Uncaria rhynchophylla among other herbs. Thus, while there is preliminary scientific support for its neuroprotective effects relevant to Alzheimer’s disease, the evidence is limited and not yet substantiated by large-scale clinical trials. Therefore, the scientific evidence for using Uncaria rhynchophylla for Alzheimer’s disease is rated as low to moderate (2/5).

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Products containing Uncaria rhynchophylla

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