Evidence supporting the use of: Vitamin B12 (various)
For the health condition: Alzheimer's Disease

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Vitamin B12 is considered to have a "scientific" rationale for its use in supporting cognitive function, including in Alzheimer's Disease (AD), primarily due to its essential role in neurological health. However, the strength of evidence supporting its use specifically for Alzheimer's Disease is weak to moderate. Vitamin B12 deficiency can cause cognitive impairment and dementia-like symptoms, which are often reversible with supplementation. Observational studies have found that low B12 levels and elevated homocysteine (which B12 helps metabolize) are associated with an increased risk of cognitive decline and dementia, including AD. Some small clinical trials have investigated whether B12 supplementation can slow cognitive decline in patients with mild cognitive impairment or Alzheimer's, particularly in those with low B12 status. These studies have shown mixed results: supplementation may benefit individuals with deficiency, but does not appear to affect cognitive decline in patients with normal B12 levels. Major reviews and meta-analyses (e.g., Cochrane, 2018; Smith et al., 2010) conclude that, while correcting B12 deficiency is important for overall health and can prevent reversible causes of cognitive impairment, there is insufficient evidence to recommend B12 supplementation as a treatment for Alzheimer's Disease itself in individuals with normal B12 status. Thus, its use is scientifically justified only for deficient individuals, with limited benefit for Alzheimer's overall.

More about Vitamin B12 (various)
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Other ingredients used for Alzheimer's Disease

acai berry
acetyl l-carnitine
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algal oil
alpha-linolenic acid (ALA)
amino acids
anthocyanins
ashwagandha
astaxanthin
berberine
berry flavor
beta caryophyllene
bifidobacterium longum
black garlic
black tea
blueberry
broccoli
butyrate triglyceride
caffeine
cannabis sativa oil
caprylic acid
catechins
Chinese salvia root
chokeberry
choline
cinnamon
citicoline
coenzyme Q10 (CoQ10)
turmeric
curcumin
cyclodextrin
d-alpha tocopherol
DHA (docosahexaeonic acid)
DPA (docosapentaenoic acid)
EPA (eicosapentaenoic acid)
epigallocatechin gallate (EGCG)
fisetin
fish oil
fish protein
flavonols
gamma tocopherol
genistein
ginkgo biloba
ginseng
glycerophosphocholine (GPC)
grape
green tea
hemp oil
hesperetin
hesperidin
huperzine A
l-carnitine
l-carnosine
l-serine
l-theanine
lentinula edodes mycelia
lion's mane
lutein
luteolin
lycopene
mackerel
magnesium
marine lipid
matcha
medium chain triglycerides (MCT)
melatonin
n-acetyl-cysteine (NAC)
naringin
niacinamide (vitamin B3)
nicotinamide riboside
olive
omega-3 fatty acids
oyster mushroom
phenolic acids
phosphatidylcholine
phosphatidylserine
phospholipids
phytocannabinoids
polygala root
pomegranate
pregnenolone
butyric acid
pyrroloquinoline disodium salt
quercetin
reishi mushroom
resveratrol
rhizome
rosemary
saffron
sage
SAMe (s-adenosyl-l-methionine disulfate p-toluensulfate)
sardines
selenium
sulforaphane glucosinolate
tocotrienols
trans-pterostilbene
tributyrin
ubiquinol
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vinpocetine
vitamin B
vitamin B12
vitamin C
vitamin D
vitamin D3
vitamin E
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gastrodia
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ganoderma
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terpene lactones
polyphenols
hypothalamus
herbal blend (proprietary)
algae
cocoa
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bacoside
Baicalin
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Camellia sinensis
Caryophyllene
Cinnamomum
Crocin
Carnosine
Catalpol
Cyanidin
Curcuminoid
Curcumen
Chinese Ligustrum berry
Creatine
Curcuma
C-Phycocyanin
Convolvulus prostratus
Crocetin
Cytidine
Carnosic acid
Cannabigerol
Docosahexaenoic Acid
Decursin
Dihydrolipoic Acid
epicatechin
Ellagic Acid
Ergothioneine
Eicosapentaenoic Acid
Estrogen
Ecklonia
Flavonoids
Fish
Fatty acids
Flavonones
Ketone Salts
walnut

Products containing Vitamin B12 (various)

We currently have no products on Vitabase that contain this ingredient.