Evidence supporting the use of: Vitamin B3 (Niacinamide)
For the health condition: Alzheimer's Disease

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

There is some scientific interest in the use of Vitamin B3 (niacinamide) for Alzheimer's Disease, but current evidence is limited and preliminary. Laboratory and animal studies have suggested that niacinamide may have neuroprotective effects, possibly by inhibiting tau phosphorylation, improving mitochondrial function, and reducing oxidative stress in neural tissue. A notable preclinical study published in "The Journal of Neuroscience" (2008) found that high doses of niacinamide improved cognitive function and reduced tau pathology in a mouse model of Alzheimer's Disease. However, human clinical trials are lacking. Only a few small-scale or early-phase studies have investigated niacinamide in Alzheimer's patients, and robust, large-scale, placebo-controlled trials have not been completed. The available human data do not provide convincing evidence to recommend niacinamide as a treatment for Alzheimer's Disease. Major guidelines and reviews, including those from the Alzheimer’s Association and Cochrane Reviews, do not endorse niacinamide for this indication due to insufficient clinical evidence. In summary, while there are plausible mechanisms and encouraging preclinical findings, the current scientific validation is weak (rated 2/5), and niacinamide should not be considered a proven or established therapy for Alzheimer's Disease at this time. Further research, particularly well-designed human studies, is needed to determine its efficacy and safety for this condition.

More about Vitamin B3 (Niacinamide)
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Other ingredients used for Alzheimer's Disease

acai berry
acetyl l-carnitine
akkermansia muciniphila
algal oil
alpha-linolenic acid (ALA)
amino acids
anthocyanins
ashwagandha
astaxanthin
berberine
berry flavor
beta caryophyllene
bifidobacterium longum
black garlic
black tea
blueberry
broccoli
butyrate triglyceride
caffeine
cannabis sativa oil
caprylic acid
catechins
Chinese salvia root
chokeberry
choline
cinnamon
citicoline
coenzyme Q10 (CoQ10)
turmeric
curcumin
cyclodextrin
d-alpha tocopherol
DHA (docosahexaeonic acid)
DPA (docosapentaenoic acid)
EPA (eicosapentaenoic acid)
epigallocatechin gallate (EGCG)
fisetin
fish oil
fish protein
flavonols
gamma tocopherol
genistein
ginkgo biloba
ginseng
glycerophosphocholine (GPC)
grape
green tea
hemp oil
hesperetin
hesperidin
huperzine A
l-carnitine
l-carnosine
l-serine
l-theanine
lentinula edodes mycelia
lion's mane
lutein
luteolin
lycopene
mackerel
magnesium
marine lipid
matcha
medium chain triglycerides (MCT)
melatonin
n-acetyl-cysteine (NAC)
naringin
niacinamide (vitamin B3)
nicotinamide riboside
olive
omega-3 fatty acids
oyster mushroom
phenolic acids
phosphatidylcholine
phosphatidylserine
phospholipids
phytocannabinoids
polygala root
pomegranate
pregnenolone
butyric acid
pyrroloquinoline disodium salt
quercetin
reishi mushroom
resveratrol
rhizome
rosemary
saffron
sage
SAMe (s-adenosyl-l-methionine disulfate p-toluensulfate)
sardines
selenium
sulforaphane glucosinolate
tocotrienols
trans-pterostilbene
tributyrin
ubiquinol
Urolithin A
vinpocetine
vitamin B
vitamin B12
vitamin C
vitamin D
vitamin D3
vitamin E
mulberry
β-nicotinamide mononucleotide (NMN)
gastrodia
tinospora cordifolia
lingzhi
morus
ferulic acid
cistanche
ganoderma
royal jelly
terpene lactones
polyphenols
hypothalamus
herbal blend (proprietary)
algae
cocoa
AMP-activated protein kinase (AMPK)
soy isoflavones
2-(carbamimidoyl-methyl-amino) ethoxyphosphonic acid
7,8-Dihydroxyflavone
7,14-Hydroxy-Docosapentaenoic Acid
Apigenin
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Anserine
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Astragaloside
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Aniracetam
Apocynin
Black Seed
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Butylphthalide
Beta-hydroxybutyrate
Bacopin
Baicalein
Benfotiamine
Basidiomycota
Brahmi
Bacopa
Bifidobacteria
bacoside
Baicalin
Caffeic Acid
Centrophenoxine
Camellia sinensis
Caryophyllene
Cinnamomum
Crocin
Carnosine
Catalpol
Cyanidin
Curcuminoid
Curcumen
Chinese Ligustrum berry
Creatine
Curcuma
C-Phycocyanin
Convolvulus prostratus
Crocetin
Cytidine
Carnosic acid
Cannabigerol
Docosahexaenoic Acid
Decursin
Dihydrolipoic Acid
epicatechin
Ellagic Acid
Ergothioneine
Eicosapentaenoic Acid
Estrogen
Ecklonia
Flavonoids
Flavonones
Ketone Salts
walnut

Products containing Vitamin B3 (Niacinamide)

We currently have no products on Vitabase that contain this ingredient.