Evidence supporting the use of: Vitamin E (alpha-tocopherol acetate)
For the health condition: Alzheimer's Disease

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Vitamin E (specifically alpha-tocopherol acetate) has been investigated for its potential role in supporting or treating Alzheimer's Disease (AD) due to its antioxidant properties, which may help protect brain cells from oxidative stress—a process implicated in AD pathogenesis. Some clinical evidence exists, most notably the 2014 randomized controlled trial by the Alzheimer's Disease Cooperative Study (ADCS), which found that high-dose vitamin E (2000 IU/day) modestly slowed functional decline in patients with mild to moderate Alzheimer's when compared to placebo or memantine. The difference, while statistically significant, was modest and did not demonstrate improvement in cognitive scores, only a delay in loss of daily living abilities. Other studies, including the 1997 Sano et al. trial, also suggested a delay in disease progression with vitamin E, but results have been inconsistent and are complicated by concerns over high-dose vitamin E safety, such as increased mortality risk in some populations. Meta-analyses and reviews highlight that, while vitamin E supplementation may have a small benefit in slowing functional decline, there is no strong evidence it improves cognition or reverses Alzheimer's progression. Most guidelines do not recommend routine use due to limited efficacy and potential risks. Thus, the use of vitamin E for Alzheimer's is scientifically investigated, but the evidence is limited and not robust.

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Products containing Vitamin E (alpha-tocopherol acetate)

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