Evidence supporting the use of: Vitamin E (mixed alpha-tocopherol)
For the health condition: Alzheimer's Disease

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Vitamin E (primarily as alpha-tocopherol) has been investigated for its potential role in supporting or treating Alzheimer's Disease (AD) due to its antioxidant properties, which may help counteract oxidative stress implicated in neurodegeneration. Several clinical trials have examined its efficacy. A notable study published in the New England Journal of Medicine in 1997 found that high-dose vitamin E (2000 IU/day) modestly delayed functional decline in patients with moderate Alzheimer's, compared to placebo. More recently, the 2014 TEAM-AD VA Cooperative Randomized Trial found that vitamin E supplementation slowed functional decline in patients with mild-to-moderate AD, though the effect size was modest and not all measures improved.

However, meta-analyses and subsequent reviews have raised concerns regarding the overall benefit and safety of high-dose vitamin E, as some studies suggest increased mortality at high doses and inconsistent cognitive outcomes. Current clinical guidelines do not recommend vitamin E as a standard treatment for AD, but acknowledge that it may have a modest benefit for some individuals. No major traditional medicine systems have a history of using vitamin E specifically for dementia or Alzheimer's.

In summary, there is some scientific evidence for vitamin E’s benefit in slowing functional decline in AD, but the effect is modest, and concerns about safety and inconsistent results limit its clinical use. The evidence supporting its use is therefore rated as 2 out of 5.

More about Vitamin E (mixed alpha-tocopherol)
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Other ingredients used for Alzheimer's Disease

acai berry
acetyl l-carnitine
akkermansia muciniphila
algal oil
alpha-linolenic acid (ALA)
amino acids
anthocyanins
ashwagandha
astaxanthin
berberine
berry flavor
beta caryophyllene
bifidobacterium longum
black garlic
black tea
blueberry
broccoli
butyrate triglyceride
caffeine
cannabis sativa oil
caprylic acid
catechins
Chinese salvia root
chokeberry
choline
cinnamon
citicoline
coenzyme Q10 (CoQ10)
turmeric
curcumin
cyclodextrin
d-alpha tocopherol
DHA (docosahexaeonic acid)
DPA (docosapentaenoic acid)
EPA (eicosapentaenoic acid)
epigallocatechin gallate (EGCG)
fisetin
fish oil
fish protein
flavonols
gamma tocopherol
genistein
ginkgo biloba
ginseng
glycerophosphocholine (GPC)
grape
green tea
hemp oil
hesperetin
hesperidin
huperzine A
l-carnitine
l-carnosine
l-serine
l-theanine
lentinula edodes mycelia
lion's mane
lutein
luteolin
lycopene
mackerel
magnesium
marine lipid
matcha
medium chain triglycerides (MCT)
melatonin
n-acetyl-cysteine (NAC)
naringin
niacinamide (vitamin B3)
nicotinamide riboside
olive
omega-3 fatty acids
oyster mushroom
phenolic acids
phosphatidylcholine
phosphatidylserine
phospholipids
phytocannabinoids
polygala root
pomegranate
pregnenolone
butyric acid
pyrroloquinoline disodium salt
quercetin
reishi mushroom
resveratrol
rhizome
rosemary
saffron
sage
SAMe (s-adenosyl-l-methionine disulfate p-toluensulfate)
sardines
selenium
sulforaphane glucosinolate
tocotrienols
trans-pterostilbene
tributyrin
ubiquinol
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vinpocetine
vitamin B
vitamin B12
vitamin C
vitamin D
vitamin D3
vitamin E
mulberry
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gastrodia
tinospora cordifolia
lingzhi
morus
ferulic acid
cistanche
ganoderma
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terpene lactones
polyphenols
hypothalamus
herbal blend (proprietary)
algae
cocoa
AMP-activated protein kinase (AMPK)
soy isoflavones
2-(carbamimidoyl-methyl-amino) ethoxyphosphonic acid
7,8-Dihydroxyflavone
7,14-Hydroxy-Docosapentaenoic Acid
Apigenin
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Astragaloside
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Apocynin
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Baicalein
Benfotiamine
Basidiomycota
Brahmi
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bacoside
Baicalin
Caffeic Acid
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Camellia sinensis
Caryophyllene
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Crocin
Carnosine
Catalpol
Cyanidin
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Curcumen
Chinese Ligustrum berry
Creatine
Curcuma
C-Phycocyanin
Convolvulus prostratus
Crocetin
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Docosahexaenoic Acid
Decursin
Dihydrolipoic Acid
epicatechin
Ellagic Acid
Ergothioneine
Eicosapentaenoic Acid
Estrogen
Ecklonia
Flavonoids
Flavonones
Ketone Salts
walnut

Products containing Vitamin E (mixed alpha-tocopherol)

We currently have no products on Vitabase that contain this ingredient.