Evidence supporting the use of: Vitamin E (mixied tocopherols and tocotrienols)
For the health condition: Alzheimer's Disease

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Vitamin E, encompassing both tocopherols and tocotrienols, has been investigated as a potential therapy for Alzheimer’s Disease (AD) due to its antioxidant properties. Oxidative stress is thought to contribute to AD pathology, and Vitamin E is a lipid-soluble antioxidant that may protect neuronal cell membranes from oxidative damage. The most significant clinical trial, the TEAM-AD VA Cooperative Randomized Trial (2014), found that high-dose alpha-tocopherol (2000 IU/d) modestly slowed functional decline in patients with mild to moderate AD compared to placebo. However, the effect size was small, and concerns were raised about increased mortality risk at high doses in some meta-analyses. Other studies, such as the Alzheimer’s Disease Cooperative Study (1997), also suggested a delay in disease progression with Vitamin E supplementation, but results have not been consistently replicated, and benefits appear limited to disease progression rather than prevention or cognitive improvement. There is less clinical evidence specifically for tocotrienols. Major guidelines generally do not recommend Vitamin E as standard therapy for AD due to limited efficacy and potential risks. In summary, while there is some scientific rationale and limited clinical evidence supporting Vitamin E’s use in AD, the overall quality and consistency of evidence are low, and routine use is not broadly endorsed.

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alpha-linolenic acid (ALA)
amino acids
anthocyanins
ashwagandha
astaxanthin
berberine
berry flavor
beta caryophyllene
bifidobacterium longum
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black tea
blueberry
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butyrate triglyceride
caffeine
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caprylic acid
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citicoline
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DHA (docosahexaeonic acid)
DPA (docosapentaenoic acid)
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epigallocatechin gallate (EGCG)
fisetin
fish oil
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flavonols
gamma tocopherol
genistein
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ginseng
glycerophosphocholine (GPC)
grape
green tea
hemp oil
hesperetin
hesperidin
huperzine A
l-carnitine
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l-serine
l-theanine
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lutein
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lycopene
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magnesium
marine lipid
matcha
medium chain triglycerides (MCT)
melatonin
n-acetyl-cysteine (NAC)
naringin
niacinamide (vitamin B3)
nicotinamide riboside
olive
omega-3 fatty acids
oyster mushroom
phenolic acids
phosphatidylcholine
phosphatidylserine
phospholipids
phytocannabinoids
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Products containing Vitamin E (mixied tocopherols and tocotrienols)

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