Evidence supporting the use of: Vitamin E (tocotrienols)
For the health condition: Alzheimer's Disease

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Vitamin E, which includes both tocopherols and tocotrienols, has been studied for its potential role in supporting or treating Alzheimer’s Disease (AD) due to its antioxidant properties. Oxidative stress is implicated in the pathogenesis of AD, and vitamin E, as a lipid-soluble antioxidant, has been hypothesized to protect neuronal membranes from oxidative damage. While most clinical studies have focused on alpha-tocopherol (the most common form of vitamin E in supplements), some interest exists regarding tocotrienols, which have demonstrated stronger antioxidant effects in laboratory studies compared to tocopherols.

However, clinical evidence specifically supporting tocotrienols for AD is very limited. The most cited clinical trials, such as the 1997 Sano et al. study and the 2014 Dysken et al. study, used high-dose alpha-tocopherol and found mixed results—some delay in functional decline, but no significant impact on cognitive outcomes or disease progression. Data on tocotrienols in human subjects with AD are sparse, with most evidence coming from preclinical models, where tocotrienols showed neuroprotective and anti-inflammatory effects.

In summary, while there is a scientific rationale based on antioxidant mechanisms and some in vitro/in vivo studies, there is insufficient high-quality clinical evidence specifically for tocotrienols in Alzheimer’s Disease. The evidence is stronger for alpha-tocopherol, but even there, benefit is modest and not universally accepted. Thus, scientific support for tocotrienols in AD is weak (rated 2/5).

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alpha-linolenic acid (ALA)
amino acids
anthocyanins
ashwagandha
astaxanthin
berberine
berry flavor
beta caryophyllene
bifidobacterium longum
black garlic
black tea
blueberry
broccoli
butyrate triglyceride
caffeine
cannabis sativa oil
caprylic acid
catechins
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citicoline
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DHA (docosahexaeonic acid)
DPA (docosapentaenoic acid)
EPA (eicosapentaenoic acid)
epigallocatechin gallate (EGCG)
fisetin
fish oil
fish protein
flavonols
gamma tocopherol
genistein
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ginseng
glycerophosphocholine (GPC)
grape
green tea
hemp oil
hesperetin
hesperidin
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l-carnitine
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l-serine
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lutein
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lycopene
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marine lipid
matcha
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niacinamide (vitamin B3)
nicotinamide riboside
olive
omega-3 fatty acids
oyster mushroom
phenolic acids
phosphatidylcholine
phosphatidylserine
phospholipids
phytocannabinoids
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pomegranate
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Products containing Vitamin E (tocotrienols)

We currently have no products on Vitabase that contain this ingredient.