Evidence supporting the use of: Walnut
For the health condition: Alzheimer's Disease

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Synopsis

Source of validity: Scientific
Rating (out of 5): 1

Walnut (Juglans regia) has been investigated for its potential neuroprotective effects, including possible benefits for Alzheimer's disease (AD). Several preclinical studies have suggested that walnuts, which are rich in polyunsaturated fatty acids (notably alpha-linolenic acid), polyphenols, and antioxidants, may help reduce oxidative stress and inflammation—factors implicated in AD pathogenesis. Animal studies have shown that walnut-enriched diets can improve memory, learning, and motor coordination in transgenic mouse models of Alzheimer's disease. Proposed mechanisms include reduction of amyloid-beta aggregation, attenuation of oxidative damage, and modulation of neuronal signaling pathways.

However, human clinical evidence is extremely limited. Most data come from small-scale, short-term studies or from observational research examining general cognitive function in older adults, rather than the treatment or prevention of diagnosed Alzheimer's disease. No large, well-controlled clinical trials have demonstrated a significant therapeutic effect of walnut consumption specifically for AD patients. Thus, while there is scientific interest and some preliminary supportive data from animal models, the overall quality and quantity of evidence in humans is weak.

In summary, the use of walnuts for Alzheimer's disease is primarily supported by preclinical findings with minimal clinical validation, resulting in a low evidence rating.

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acai berry
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akkermansia muciniphila
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alpha-linolenic acid (ALA)
amino acids
anthocyanins
ashwagandha
astaxanthin
berberine
berry flavor
beta caryophyllene
bifidobacterium longum
black garlic
black tea
blueberry
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butyrate triglyceride
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citicoline
coenzyme Q10 (CoQ10)
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cyclodextrin
d-alpha tocopherol
DHA (docosahexaeonic acid)
DPA (docosapentaenoic acid)
EPA (eicosapentaenoic acid)
epigallocatechin gallate (EGCG)
fisetin
fish oil
fish protein
flavonols
gamma tocopherol
genistein
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ginseng
glycerophosphocholine (GPC)
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green tea
hemp oil
hesperetin
hesperidin
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l-carnitine
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l-serine
l-theanine
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lutein
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lycopene
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marine lipid
matcha
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melatonin
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naringin
niacinamide (vitamin B3)
nicotinamide riboside
olive
omega-3 fatty acids
oyster mushroom
phenolic acids
phosphatidylcholine
phosphatidylserine
phospholipids
phytocannabinoids
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pregnenolone
butyric acid
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quercetin
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walnut

Products containing walnut

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