Evidence supporting the use of: Agnuside
For the health condition: Amenorrhea

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Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Agnuside is a major iridoid glycoside found in the fruit of Vitex agnus-castus (chaste tree), a plant with a long history of use in traditional herbal medicine, particularly in Europe and the Mediterranean. Historically, Vitex agnus-castus has been used to address various menstrual disorders, including amenorrhea (absence of menstruation). The traditional rationale is based on the plant's reputed ability to balance female hormones and restore normal menstrual cycles. Agnuside is considered one of the key active compounds in chaste tree fruit, and it is often used as a marker for standardization of extracts. However, while there is substantial traditional use of Vitex agnus-castus for amenorrhea, direct scientific evidence specifically focusing on agnuside itself is limited. Most clinical studies and reviews evaluate whole plant extracts rather than isolated agnuside. Some research indicates that chaste tree extracts may influence prolactin secretion via dopaminergic pathways, potentially helping to regulate menstrual cycles, but agnuside’s individual role in these effects is not well delineated. Therefore, the support for agnuside in treating amenorrhea relies primarily on historical use and extrapolation from studies on the whole plant, rather than robust clinical trials on the isolated compound.

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