Evidence supporting the use of: Blue Cohosh
For the health condition: Amenorrhea

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Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Blue Cohosh (Caulophyllum thalictroides) has a long history of use in traditional herbal medicine, particularly among Native American and 19th-century Western herbalists, to support menstrual health and address conditions such as amenorrhea (absence of menstruation). Historical records indicate that Blue Cohosh was used by some indigenous groups and later by eclectic physicians to stimulate menstrual flow, often as part of broader "female tonic" formulas. The purported mechanism was its emmenagogue action—meaning it was thought to stimulate uterine contractions and promote menstruation. However, modern scientific research on Blue Cohosh for amenorrhea is scant. There are no well-designed clinical trials evaluating its efficacy for this particular condition, and the pharmacological studies that exist primarily focus on its potential uterotonic and labor-inducing effects, rather than amenorrhea specifically. Additionally, safety concerns have been raised regarding Blue Cohosh, as some of its constituents may have toxic effects, particularly during pregnancy. In summary, while tradition supports the use of Blue Cohosh for amenorrhea, robust scientific validation is lacking, and its use is not recommended without professional guidance due to safety concerns.

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