Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Chasteberry (Vitex agnus-castus) has a long history of use in traditional herbal medicine, particularly in Europe, for addressing various menstrual disorders, including amenorrhea (the absence of menstruation). Historical texts and traditional herbal compendia document its use for “restoring menstrual flow” and balancing female hormones. The proposed mechanism is largely attributed to its dopaminergic effects, which may help modulate prolactin levels and thus influence the hypothalamic-pituitary-ovarian axis.

However, scientific evidence specifically supporting chasteberry for amenorrhea is limited. Most modern clinical trials and reviews focus on its effects for premenstrual syndrome (PMS), premenstrual dysphoric disorder (PMDD), or mastalgia (breast pain), with some evidence suggesting it can regulate menstrual cycles in cases of mild hyperprolactinemia or luteal phase defects. There are a few small studies and case reports indicating potential benefit in women with amenorrhea, but these are neither large nor robust enough to provide strong scientific validation.

In summary, chasteberry’s use for amenorrhea is primarily supported by tradition and historical practice, with weak to modest indirect scientific rationale but insufficient high-quality clinical evidence specifically for this indication.

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