Evidence supporting the use of: Human Chorionic Gonadotropin
For the health condition: Amenorrhea

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Human Chorionic Gonadotropin (hCG) has a scientific basis for use in the treatment of amenorrhea, particularly in cases where amenorrhea is due to anovulation (failure of the ovary to release eggs). hCG is a hormone produced during pregnancy that mimics the action of luteinizing hormone (LH), which is critical for ovulation. In clinical practice, hCG is sometimes used as part of ovulation induction protocols, especially in women undergoing fertility treatments. The rationale is that hCG can trigger ovulation in women with amenorrhea due to disrupted LH surge.

However, the strength of evidence is moderate at best. Most clinical guidelines recommend clomiphene citrate or letrozole as first-line treatments for anovulatory amenorrhea, with hCG used more specifically to induce ovulation after follicular development has been achieved with other agents (such as gonadotropins). There are few robust studies evaluating hCG alone for the treatment of amenorrhea outside the context of assisted reproductive technologies. Thus, while there is a scientific rationale and some clinical use, its routine use for amenorrhea outside of fertility protocols is not well-supported by high-quality evidence. The evidence rating is therefore a 2 out of 5.

References:
- American College of Obstetricians and Gynecologists. (2022). Management of Anovulatory Bleeding.
- Practice Committee of the American Society for Reproductive Medicine. (2013). Use of exogenous gonadotropins.

More about Human Chorionic Gonadotropin
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