Evidence supporting the use of: Peony (unspecified)
For the health condition: Amenorrhea

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Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Peony, particularly the root of Paeonia lactiflora (commonly known as white peony), has a long history of use in traditional Chinese medicine (TCM) for the management of gynecological disorders, including amenorrhea (the absence of menstruation). In TCM, peony root is often included in formulas such as Shao Yao Gan Cao Tang and is believed to nourish the blood, regulate menstruation, and alleviate pain. Its use is based on the traditional understanding that amenorrhea may be caused by blood deficiency or stagnation, and peony is thought to help restore balance. Modern scientific studies on peony’s effects on amenorrhea are limited. Some research suggests that peony, especially in combination with other herbs like licorice (as in the traditional formula), may influence hormonal regulation, specifically by modulating the hypothalamic-pituitary-ovarian axis. A few small clinical studies and in vitro experiments have shown that compounds in peony may have mild estrogenic effects and could support ovarian function, but these findings are preliminary and not sufficient for strong clinical recommendations. Overall, while peony’s use for amenorrhea is well-established in traditional medicine systems, high-quality scientific evidence supporting its efficacy is limited. The rating of 2 reflects the predominance of traditional use with some, but not robust, scientific exploration.

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