Evidence supporting the use of: Progesterone
For the health condition: Amenorrhea

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Synopsis

Source of validity: Scientific
Rating (out of 5): 5

Progesterone is scientifically validated for the treatment of amenorrhea, particularly in cases of secondary amenorrhea due to anovulation or hormonal imbalance. Amenorrhea, the absence of menstruation, can result from insufficient production of progesterone during the menstrual cycle. In a normal cycle, ovulation triggers progesterone secretion from the corpus luteum, which prepares the endometrium for possible pregnancy. If ovulation does not occur, endogenous progesterone is not produced, and the endometrial lining may not be shed, resulting in amenorrhea.

Medical practice utilizes progesterone therapy or synthetic progestins to induce withdrawal bleeding, thereby confirming the presence or absence of endogenous estrogen and assessing the integrity of the hypothalamic-pituitary-ovarian axis. Randomized controlled trials and clinical guidelines (e.g., American College of Obstetricians and Gynecologists, Endocrine Society) support the use of cyclic progesterone or progestins for inducing withdrawal menses in women with secondary amenorrhea who have adequate endogenous estrogen. This approach is both diagnostic and therapeutic in differentiating the underlying etiology of amenorrhea and in reducing the risk of endometrial hyperplasia that may result from unopposed estrogen exposure.

Thus, the use of progesterone for amenorrhea is based on an extensive scientific foundation, with decades of clinical use, mechanistic understanding, and guideline recommendations supporting its efficacy and safety in properly selected patients.

More about Progesterone
More about Amenorrhea

Products containing Progesterone

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