Evidence supporting the use of: Rue
For the health condition: Amenorrhea

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Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Rue (Ruta graveolens) has a long history of use in traditional medicine, particularly in Mediterranean and Middle Eastern cultures, as an emmenagogue—a substance believed to stimulate menstrual flow. Historical texts, including ancient Greek and Roman medical writings, refer to rue’s use in treating amenorrhea (absence of menstruation) as well as other reproductive complaints. Traditional herbalists have attributed its effects to the presence of various phytochemicals, such as rutin and volatile oils, which were thought to exert a stimulant effect on the uterus. However, clinical trial data validating these claims are lacking. Most of the available evidence is anecdotal or comes from historical sources rather than modern scientific studies. Some case reports and ethnobotanical surveys mention its use, but robust pharmacological research on rue for amenorrhea is minimal. Additionally, rue can be toxic at higher doses and is known to have abortifacient properties, which warrants caution. Overall, while rue’s use for amenorrhea is well documented in traditional medicine, this application is not strongly supported by contemporary scientific evidence.

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